MCQ’S GENERAL PATHOLOGY- REVERSIBLE CELL INJURY with answers and explanations

1. A 50 year old man presented with mild abdominal pain with mildly raised ALT and AST.  Fatty liver was suspected,  which of the following changes is not seen ultrastructurally in this condition?

A)  Generalized swelling of cell and plasma membrane.

B)  Nuclear changes such as pyknosis,  karyorrhexis and karyolysis are seen.

C) Accumulation of “myelin figures” in the cytosol composed of phospholipids derived from damaged cellular membranes.

D) Dilation of the ER, with detachment of polysomes.

Answer: B.  Pyknosis,  karyorrhexis and karyolysis are classic features of apoptosis

2. What is the mechanism behind plasma membrane swelling in reversible cell injury?

A)  Influx of water due to direct damage to Na-K-ATPase pump

B)  Plasma menrane damage leading to increased leakiness to sodium ion.

C)  Depletion of ATP resulting in oxygen deficiency interfering in Na-K-ATPase pump activity.

D)  All of the above

Answer:  D

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Check out this excellent blog  on more knowledge and details on this topic:  https://theartofmed.wordpress.com/2015/05/29/pathologic-cell-injury-and-cell-death-i-mechanism-of-reversible-cell-injuries/amp/