Certain lymphomas and leukemias have a very specific genetic translocations.
It is not only important for diagnostic purposes, but also for treatment. Here are a few very important ones medical students must know.
1. Acute lymphocytic leukemia (ALL)– t(12;21)
2. Acute myeloid leukemia (AML)
a) t(8;21) – fusion of RUNX-RUNX1
b) t(15;17) – fusion of PML-RARA
c) inv (3)
3. Chronic myeloid leukemia– t(9;22) results in BCR-ABL fusion gene.
4. Burkitt lymphoma– Most common translocation in Burkitt lymphoma is t(8;14)
5. Follicular lymphoma– t(14;18)
6. Mantle cell lymphoma – t(11;14)
7. MALT- lymphoma – t(11;18)
Check out the video for more info:
If you are interested in bad mnemonics check this out
If you are interested in bad mnemonics check this out!
Interested in more illustrations related to hematology? Check this out!!
Check this link out for multiple choice questions in hematology.