Certain lymphomas and leukemias have a very specific genetic translocations.
It is not only important for diagnostic purposes, but also for treatment. Here are a few very important ones medical students must know.
1. Acute lymphocytic leukemia (ALL)– t(12;21)
2. Acute myeloid leukemia (AML)
a) t(8;21) – fusion of RUNX-RUNX1
b) t(15;17) – fusion of PML-RARA
c) inv (3)
3. Chronic myeloid leukemia– t(9;22) results in BCR-ABL fusion gene.
4. Burkitt lymphoma– Most common translocation in Burkitt lymphoma is t(8;14)
5. Follicular lymphoma– t(14;18)
6. Mantle cell lymphoma – t(11;14)
7. MALT- lymphoma – t(11;18)

Interested in more illustrations related to hematology? Check this out!!
Check this link out for multiple choice questions in hematology.
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