PEUTZ-JEHERS SYNDROME IS AN AUTOSOMAL DOMINANT DISORDER. VARIOUS MEDICAL CONDITIONS ARE ASSOCIATED WITH PEUTZ-JEHERS SYNDROME.
Peutz-Jehers syndrome is an autosomal dominant genetic disorder characterized by the development of benign hamartomatous polyps predominantly in the gastrointestinal tract. Hyperpigmented macules are present in oral mucosa, lips etc. It is associated with SKT11 (LKB1) mutation.
Peutz-Jehers syndrome is associated with various cancers, here are some conditions which when present alerts the clinician to check for an underlying syndrome.
- sex cord tumors with annular tubules (SCTAT)
- adenoma malignum of the cervix
- Sertoli cell tumors (sct)
- FEMALE ADENEXAL TUMOR OF PROBABLE WOLFFIAN ORIGIN (FATWO)
- OTHER CANCERS SUCH AS CARCINIMA BREAST, COLON, PANCREAS, OVARY AND CERVIX
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