Pathogenesis of type I and type II Serous Ovarian Carcinomas

Pathogenesis of Type I and Type II serous ovarian cancers are entirely different. We will discuss the differences.

Most of the human cancers have a steady and known progression curve. Low grade cancers usually progress to high grade. This is not the case in ovarian cancers, high grade and low grade serous carcinoma have different pathogenesis.

Unlike most human cancers serous ovarian cancers rarely progress from low grade to high grade

PATHOGENESIS OF TYPE I SEROUS OVARIAN CANCERS – Progression

Type I ovarian carcinoma is associated with endometriosis, it progresses to serous borderline tumor which may transform to micropapillary serous carcinoma and then into low grade serous carcinoma.

1.Endometriosis

2.Serous borderline tumor

3. Micropapillary serous carcinoma

4. Low grade serous ovarian carcinoma

PATHOGENESIS OF TYPE II SEROUS OVARIAN CANCERS – Progression

Type II ovarian carcinoma is associated with simple inclusion cysts, it progresses to serous tubular intraepithelial carcinoma which may transform to high grade serous carcinoma.

  1. Simple inclusion cysts

2. STIC Lesions (Serous tubular intraepithelial lesions)

3. High grade serous ovarian carcinoma

Type I serous ovarian carcinomaType II serous ovarian carcinoma
Less frequentMore frequent
Histologic types include endometrioid, serous, mucinous and clear cellHistologic types include serous tumos
Mutations include KRAS, BRAF, CTNNB1, PTEN and ERBB2Mutations include mostly p53
Low gradeHigh grade

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