Pathogenesis of Type I and Type II serous ovarian cancers are entirely different. We will discuss the differences.
Most of the human cancers have a steady and known progression curve. Low grade cancers usually progress to high grade. This is not the case in ovarian cancers, high grade and low grade serous carcinoma have different pathogenesis.
PATHOGENESIS OF TYPE I SEROUS OVARIAN CANCERS – Progression
Type I ovarian carcinoma is associated with endometriosis, it progresses to serous borderline tumor which may transform to micropapillary serous carcinoma and then into low grade serous carcinoma.
2.Serous borderline tumor
3. Micropapillary serous carcinoma
4. Low grade serous ovarian carcinoma
PATHOGENESIS OF TYPE II SEROUS OVARIAN CANCERS – Progression
Type II ovarian carcinoma is associated with simple inclusion cysts, it progresses to serous tubular intraepithelial carcinoma which may transform to high grade serous carcinoma.
- Simple inclusion cysts
2. STIC Lesions (Serous tubular intraepithelial lesions)
3. High grade serous ovarian carcinoma
|Type I serous ovarian carcinoma||Type II serous ovarian carcinoma|
|Less frequent||More frequent|
|Histologic types include endometrioid, serous, mucinous and clear cell||Histologic types include serous tumos|
|Mutations include KRAS, BRAF, CTNNB1, PTEN and ERBB2||Mutations include mostly p53|
|Low grade||High grade|
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