6 KEY POINTS TO REMEMBER FOR BOARDS – ACUTE LYMPHOCYTIC LEKUKEMIA- t(5;14)

1. Basts harbour a translocation between IL3 and an IGH gene, resulting in variable eosinophilia
2. This diagnosis can be made on the basis of immunophenotypic and genetic findings even if the bone marrow blast count is low.
3. patients may present with an asymptomatic eosinophilia,
4. Blasts may be deceptively absent in the peripheral blood.
5. Eosinophils are a reactive popula­ tion and not part of the leukaemic clone.
6. The prognosis is not considered to be different from that of other types of ALL

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