6 KEY POINTS TO REMEMBER FOR BOARDS – ACUTE LYMPHOCYTIC LEKUKEMIA- t(5;14)
- Basts harbour a translocation between IL3 and an IGH gene, resulting in variable eosinophilia
- This diagnosis can be made on the basis of immunophenotypic and genetic findings even if the bone marrow blast count is low.
- patients may present with an asymptomatic eosinophilia,
- Blasts may be deceptively absent in the peripheral blood.
- Eosinophils are a reactive popula tion and not part of the leukaemic clone.
- The prognosis is not considered to be different from that of other types of ALL
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