Molecular pathogenesis of ovarian epithelial tumors.

Molecular progression of serous ovarian tumor. Borderline low and high grade

1.Molecular progression of low grade ovarian serous tumors.
There is data to suggest progression from serous cystadenoma / cystadenofibroma with BRAF / KRAS mutations → SBT (serous borderline tumor) → LGSC (Low grade serous carcinoma) ; however, this is still controversial

2. Molecular progression of high grade serous ovarian tumors.

TP53 alterations in nearly all cases of high grade serous carcinoma

Germline, somatic or promoter hypermethylation (inactivation) of BRCA1 and BRCA2 in ~50% of cases

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