CAN YOU GUESS THE TYPE OF LEIOMYOMA BASED ON THE MORPHOLOGY?

Here are a few images, all you got to do is to guess the type of genetic mutation in the leiomyoma just based on the morphology.

Focus on the nucleus…
Spindle to oval shaped nucleus with bright eosinophilic nucleoli surrounded by a halo.
See those rhabdoid eosinophilic inclusions?

What do you think the type of leiomyoma is?

A. Leiomyoma with bizzare nuclei

B. Fumarate hydratase deficient leiomyoma

C. Cellular leiomyoma

D. Mitotically active leiomyoma

ANSWER

The correct answer is B- Fumarate hydratase deficient leiomyoma.

Option A: Leiomyoma with bizzare nuclei does not have an eosinophilic nucleoli.

Option C: Cellular leiomyoma is more cellular than the adjacent myometrium.

Option D: Mitotically active leiomyoma has a mitosis of > 4-10/ HPF

DIFFERENCE BETWEEN FUMARATE HYDRATASE DEFICIENT LEIOMYOMA AND LEIOMYOMA WITH BIZZARE NUCLEI

Difference between leiomyoma with bizzare nuclei and fumarate hydratase deficient leiomyoma.
FIND A RELEVANT TWEETORIAL
Tweetorial

You cannot copy content of this page

%d bloggers like this: