Here are a few images, all you got to do is to guess the type of genetic mutation in the leiomyoma just based on the morphology.

What do you think the type of leiomyoma is?

A. Leiomyoma with bizzare nuclei

B. Fumarate hydratase deficient leiomyoma

C. Cellular leiomyoma

D. Mitotically active leiomyoma

ANSWER

The correct answer is B- Fumarate hydratase deficient leiomyoma.

Option A: Leiomyoma with bizzare nuclei does not have an eosinophilic nucleoli.

Option C: Cellular leiomyoma is more cellular than the adjacent myometrium.

Option D: Mitotically active leiomyoma has a mitosis of > 4-10/ HPF

DIFFERENCE BETWEEN FUMARATE HYDRATASE DEFICIENT LEIOMYOMA AND LEIOMYOMA WITH BIZZARE NUCLEI

FIND A RELEVANT TWEETORIAL

Can you guess the genetic mutation in this leiomyoma based on the histopathology? #PathTwitter #pathboards #pathresidents #pathologymcq #pathology #MedTwitter #histopathology #histology #fgtpath #dmhistopathology #frcpath1 #rcpath #frcpath #pathtweet #pathtweetorial #tweetorial pic.twitter.com/vX1N0n6ZCY

— Pathology mcqs (@Pathology_mcqs) October 9, 2022