TRUE NUCLEAR INCLUSIONS
CAUSES:
- Viral particles
- Accumulation of extracellular substances (surfactant, glycogen, polyglutamates etc) and Neuronal inclusions.
1. VIRAL PARTICLES










2. ACCUMULATION OF EXTRACELLULAR SUBSTANCES






PSEUDO-NUCLEAR INCLUSIONS
Caused by cytoplasmic invagination

SOME DIFFERENCES BETWEEN NUCLEAR INCLUSIONS, PSEUDO-INCLUSIONS AND PSEUDO-PSEUDO INCLUSIONS

Illustration credit: https://twitter.com/VijayPatho
REVIEW QUESTION
Which of the following virus does not produce intra-nuclear inclusions? (Question from AIIMS SR exam Jan 2023)
A. Varicella zoster virus
B. Variola
C. Herpes simplex
D. Polio
CLICK FOR ANSWER
Answer is B. Variola
EXPLANATION
Causes of intra-nuclear viral inclusions
Nuclear eosinophilic (acidophilic)-
- Cowdry bodies type A in Herpes simplex virus and Varicella zoster virus
- Torres bodies in yellow fever
- Cowdry bodies type B in polio and adenovirus
Nuclear basophilic-
- Cowdry bodies type B in adenovirus
- “Owl’s eye appearance” in cytomegalovirus
Both nuclear and cytoplasmic-
- WarthinโFinkeldey bodies in measles and HIV/AIDS
MORE EXPLANATION
Variola has cytoplasmic inclusions known as Guarnieri bodies

Leave a Reply