NUCLEAR INCLUSIONS AND PSEUDO-INCLUSIONS

TRUE NUCLEAR INCLUSIONS

CAUSES:

  1. Viral particles
  2. Accumulation of extracellular substances (surfactant, glycogen, polyglutamates etc) and Neuronal inclusions.

1. VIRAL PARTICLES

2. ACCUMULATION OF EXTRACELLULAR SUBSTANCES

PSEUDO-NUCLEAR INCLUSIONS

Caused by cytoplasmic invagination

SOME DIFFERENCES BETWEEN NUCLEAR INCLUSIONS, PSEUDO-INCLUSIONS AND PSEUDO-PSEUDO INCLUSIONS

Illustration credit: https://twitter.com/VijayPatho

REVIEW QUESTION

Which of the following virus does not produce intra-nuclear inclusions? (Question from AIIMS SR exam Jan 2023)

A. Varicella zoster virus

B. Variola

C. Herpes simplex

D. Polio

CLICK FOR ANSWER

Answer is B. Variola

EXPLANATION

Causes of intra-nuclear viral inclusions

Nuclear eosinophilic (acidophilic)-

  • Cowdry bodies type A in Herpes simplex virus and Varicella zoster virus
  • Torres bodies in yellow fever
  • Cowdry bodies type B in polio and adenovirus

Nuclear basophilic-

  • Cowdry bodies type B in adenovirus
  • “Owl’s eye appearance” in cytomegalovirus

Both nuclear and cytoplasmic-

  • Warthin–Finkeldey bodies in measles and HIV/AIDS
MORE EXPLANATION

Variola has cytoplasmic inclusions known as Guarnieri bodies

FIND TWEETORIALS ON THE TOPIC

You cannot copy content of this page

%d bloggers like this: