Posted in Histopathology, Neuropathology, pathology

CENTRAL CHROMATOLYSIS

Central chromatolysis is a condition seen in neurons with axonal reaction.

Lets look at the details now.

  1. Axonal reaction is a change observed in the cell body during regeneration of the axon; it is best seen in anterior horn cells of the spinal cord when motor axons are cut or seriously damaged.
  2. The increase in protein synthesis that occurs in response to the injury is reflected in enlargement and rounding up of the cell body, peripheral displacement of the nucleus, enlargement of the nucleolus, and dispersion of Nissl substance from the center to the periphery of the cell (central chromatolysis).

Below is a pictorial difference between normal neurons and neurons with axonal reaction.

REVIEW QUESTIONS

1. Axonal reaction is visible in which of the which of the following regions of the central nervous system?

A. Posterior horn cells of the spinal cord

B. Anterior horn cells of the spinal cord

C. Cerebral cortex

D. Cerebellum

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Answer is B: Axonal reaction is a change observed in the cell body during regeneration of the axon; it is best seen in anterior horn cells of the spinal cord when motor axons are cut or seriously damaged

2. Dispersion of nissil substance to the periphery of a neuron is characteristic of which of the following?

A. Axonal reaction

B. Wallerian degeneration

C. Neuronal degeneration

D. Red neurons.

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Answer is A:

The process described in the question is central chromatolysis and is associated with axonal reaction.

Posted in Histopathology, Molecular pathology, WEEKLY QUIZZES

MOLECULAR PATHOLOGY QUIZ

MOLECULAR PATHOLOGY QUIZ.

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Posted in Female genital pathology, Histopathology

Familial biparental complete hydatidiform mole (CHM)

Familial biparental complete hydatidiform mole (CHM) – An update


👪 Represents 0.6 to 2.6% of CHM.


👪 Mutations of the NLRP7 on chr 19p and KHDC3L on chr 6p.

👪 Conventional CHM are usually of paternal origin (androgenic diploidy) , in contrast to familial CHM which are biparental .


👪 Autosomal recessive inheritance


👪 Patients present with recurrent complete hydatidiform mole.(CHM)


👪 Testing for p57 is negative similar to sporadic CHM.

Update WHO 2020 FGT.

Review question

Which of the following statements is false regarding Familial biparental complete hydatidiform mole (FBCHM)?
A) This condition is inherited in an autosomal recessive manner.
B) Germline mutations in NLRP7 are common
C) Patients present with recurrent complete hydatidiform mole (CHM)
D) P57 testing by Immunohistochemistry (IHC) is positive in cytotrophoblasts unlike complete mole.

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Correct answer is D: P57 testing by Immunohistochemistry (IHC) is negative in cytotrophoblasts complete mole both familial and sporadic CHM.

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