Posted in Histopathology, Nephropathology

5 Differences between perilobar and intralobar nephrogenic rests.

Nephrogenic rests are abnormally per­ sistent foci of embryonal cells (still pre­ sent after 36 weeks of gestation) that are potentially capable of developing into nephroblastoma (also called Wilms tumour). The presence of diffuse or multifocal nephrogenic rests is called nephroblastomatosis.

Nephrogenic rests are found in 25-40% of patients with nephroblastoma, and in approximately 1% of term infant autop­sies.

Nephrogenic rests can be found adjacent to nephroblastoma or in the surrounding renal parenchyma. They are classified into perilobar and intralobar types.

Here are 5 differences between perilobar and intralobar nephrogenic rests.

1. LOCATION

Perilobar nephrogenic rests are peripherally located, wheras intralobar nephrogenic rests are randomly intermingled between the renal parenchyma, typically located in the central areas of the lobe.

2. DEMARCATION FROM ADJACENT PARENCHYMA

Perilobar nephrogenic rests are sharply demarcated from the surrounding tissue, whereas intralobar nephrogenic rests are poorly de­marcated, usually infiltrate among native nephrons.

3. STROMA

Perilobar nephrogenic rests have scanty stroma, whereas intralobar nephrogenic rests are and are composed mainly of stromal and epithelial elements.

4. FOCALITY

Perilobar nephrogenic rests are usually multifocal whereas, intralobar nephrogenic rests are mostly unifocal (often single).

5. ASSOCIATED CONDITIONS

Perilobar nephrogenic rests are associated with hemihypertrophy and overgrowth syndromes such as Beckwith-Wiede­mann syndrome. lntralobar nephrogenic rests are associated with Denys-Drash syndrome (which is associated with nephroblastoma, pseudohermaphrodit­ ism, glomerulopathy, and renal failure) and WAGR syndrome (Wilms tumour / nephroblastoma, aniridia, genitourinary anomalies, and mental retardation syn­drome).

PERILOBAR AND INTRALOBAR NEPHROGENIC RESTS HISTOPATHOLOGIC PICTURES.

Difference between perilobar and intralobar nephrogenic rests.
Posted in Histopathology, Nephropathology, WEEKLY QUIZZES

Renal pathology quiz

Renal pathology quiz on 18/06/21

Useful for Pathology residents preparing for, NEET-SS/ DM- Oncopathology/ DM Histopathogy, Nephropathology Fellowships, FRCPath- Histopathology, American Board of anatomic and clinical pathology

More quizzes below.

Posted in Female genital pathology, Histopathology

Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion

Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion

Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion.
🎯📟PSTT – invasion is periphery to lumen.
🎯📟Choriocarcinoma- lumen to periphery.

Posted in Histopathology, Oncopathology

Tips to study for NEET-SS Oncopathology

NEET-SS Oncopathology is an entrance examination conducted once every year in AUGUST -SEPTEMBER

Anyone aspiring to become an Oncopathologist in India is supposed to clear the exam after completion of the primary degree(MD/DNB).

NEET-SS is an entrance examination conducted once every year in AUGUST -SEPTEMBER.  Anyone aspiring to become an Oncopathologist in India is supposed to clear the exam after completion of the primary degree(MD/DNB).   Every year thousands of aspirants attempt the examination. However, there are merely 13 seats for the said course. Hence the competition is high.  Proper planning and the right resources will definitely get you through.     Here is a step wise approach to study for NEET-SS Oncopathology.  Read Robbins pathologic basis of disease thoroughly- cover to cover. Read histotechniques, grossing and staining and revise them from your MD notes    Here are a few very important topics to cover. Choose either Rosai Ackerman or Sternberg to cover these topics based on your comfort. *Gastrointestinal pathology. *Male and female genital. *Salivary gland *Breast and *Thyroid. WHO updates and recent classifications as well as TNM staging. Revise and you are good to go.
NEET-SS Oncopathology study tips

Every year thousands of aspirants attempt the examination. However, there are merely 13 seats for the said course. The competition is high, ever increasing for NEET-SS Oncopathology.

Proper planning and the right resources will definitely get you through”

Here is a step wise approach to study for NEET-SS Oncopathology.

  1. Read Robbins pathologic basis of disease thoroughly- cover to cover.
  1. Read histotechniques, grossing and staining and revise them from your MD notes
  1. Here are a few very important topics to cover. Choose either Rosai Ackerman or Sternberg to cover these topics based on your comfort. *Gastrointestinal pathology. *Male and female genital. *Salivary gland *Breast and *Thyroid.
  1. WHO updates and recent classifications as well as TNM staging.
  1. Revise and you are good to go.

“So many things are possible, just as long as you don’t know they are impossible.”

–Norton Juster

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For weekly multiple choice questions based on the pattern of NEET-SS oncopathology. You my check this site- HOME – Pathology for all

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Hope you found this useful.

Posted in Histopathology, Soft tissue pathology

CHENILLE BODIES IN ELASTOFIBROMA

The fragments of elastic fibers seen in elastofibroma are typically arranged linearly, creating a “beads on a string” appearance, and are known as chenille bodies.

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