CNS TUMOR QUIZ (16/05/2021)-ANSWERS Central nervous system tumors questions with answers – Useful for NEET-SS Oncopathology, DM Histopathology, NIMHANS- Neuropathology fellowships and FRCPath-Histopathology. LIKED THE QUIZ? CLICK TO LEAVE A TIP Classic astrocytoma has which of following microscopic features? A. Widespread concentric calcifications B. Fibrillary astrocytes in the background of loosely structured microcysts. C. Cells with rounded vesicular nuclei with small distinct nucleoli, perinuclear halos, chicken wire vessels D. Microvascular proliferation and geographic necrosis Answer: B Explanation: Fibrillary astrocytoma is the classic type of diffuse astrocytoma and is no longer listed as a variant Option A: Is seen in psammomatous meningiomaOption C: Is seen in oligodendrogliomaOption D: Is seen in Glioblastoma multiforme 2. Most IDH- mutant diffuse astrocytomas have which of the following mutations? A. R132G B. R132L C. R132H D. R132S Answer: C Most IDH-mutant diffuse astrocytomas haveR132H mutations. 3. Which of the following statements are true regarding astrocytomas? A. Diffuse astrocytomas do not progress to IDH-mutant glioblastoma B. IDH-mutant diffuse astrocytoma’s and IDH-wildtype glioblastomas develop from the same precursor population C. IDH-mutant astrocyomas have a better prognosis compared to IDH- wildtype D. Among IDH wildtype tumours, a genotype of 7q gain and 10q loss have a favourable outcome Answer: C Explanation: Option A: Diffuse astrocytomas have an intrinsiccapacity for malignant progression toIDH-mutant anaplastic astrocytoma andeventually to IDH-mutant glioblastoma. Option B: The available evidence suggests thatIDH-mutant and 1p/19q-codeleted oligodendrogliomas, IDH-mutant diffuse astrocytomas, IDH-mutant anaplastic astrocytomas, and IDH-mutant glioblasotomas develop from a distinct population of precursor cells that differ from the precursor cells of IDH-wildtype glioblastoma. Option D: Among IDH wildtype tumours, a genotype of 7q gainand 10q loss is associated with a particularly poor outcome. 4. For a diagnosis of gemistocytes what is The cut-off percentage of gemistocytes required? A. 50% B. 30% C. 20% D. 10% Answer: C Explanation: For a diagnosis of Gemistocytic astrocytoma, gemistocytes should constitutemore than approximately 20% of all tumor cells. The presence of occasional gemistocytes in a diffuse astrocytomadoes not justify the diagnosis. 5. Which one of the following is described among one of the Secondary structures of scherer? A. Geographic necrosis B. Perineural satellitosis C. Microvascular proliferation D. Scattered dense eosinophilic structures Answer: B Secondary structures of Scherer, including perineuronal satellitosis, perivascularaggregation, subpial spread and spread along the white matter tracts. 6. Most common genetic alteration associated with IDH-wildtype glioblastoma multiforme is? A. TERT promoter mutations B. Homozygous deletion of CDKN2A C. Loss of chromosomes 10p D. EGFR alterations Answer: A Explanation: TERT promoter mutations (present in ~80%of cases)Homozygous deletion of CDKN2A/CDKN2B (~60%)Loss of chromosomes 10p (~50%)EGFR alterations (~55%)PTEN mutations/deletion (~40%)TP53 mutations {25-30%) andPI3K mutations (~25%) 7. All of the following brain tumors show p53 mutations except? A. Primary glioblastoma in a child B. Primary glioblastoma in an adult C. Giant cell glioblastoma D. None of the above Answer: B Explanation: Primary glioblastomas do no show p53 mutations with an exception of Primary GBM in a child and giant cell glioblastoma. 8. All of the following brain tumors are associated with BRAF mutations except? A. Supratentorial pilocytic astrocytoma B. Ganglioglioma C. Pleomorphic xanthoastrocytoma D. Glioblastoma Answer: D 9. Which of the following features indicate an atypical meningioma (WHO grade II)? A. Meningioma with 4 mitoses per 10 high-power fields B. Meningioma with 20 mitoses per 10 high-power fields C. Meningioma with necrosis but no other worrying features D. Meningioma with CEA-immunopositive, PAS-positive secretory globules. Answer: A Explanation: Atypical meningioma (WHO grade II) is defined as having 4 or more mitoses per 10 high-power fields.Ana plastic meningioma (WHO grade Ill) is defined as having 20 or more mitoses per 10 high-power fields.An alternative definition of atypical meningioma (WHO grade II) require three or more of the following:increased cellularity, small cells with high nucleocytoplasmic ratio, prominent nucleoli, sheet like growth andnecrosis. Necrosis alone is insufficient for the diagnosis.Meningioma with CEA-immunopositive material indicates the so-called “secretory” subtype of meningioma(WHO grade I). Such tumors may produce measurable levels of carcinoembryonic antigen in the serum) 10. True regarding small cell glioblastoma is? A. Tumor cells show severe nuclear atypia B. Often associated with EGFR amplification C. Most of the tumors are IDH-mutated D. All of the above Answer: B Explanation: Small cell glioblastomas show little nuclear atypia, most are IDH-wild type and often EGFR amplifies. 11. Identify the variant of glioblastoma from the image? IDENTIFY THE VARIANT OF GLIOBLASTOMA A. Small cell glioblastoma B. Glioblastoma with epithelial component C. Granular cell glioblastoma D. Adenoid glioblastoma Answer: B Explanation: Cells with a granular, periodic acid Schiff-positive cytoplasm may be scattered within glioblastoma. In rare cases,they dominate and create the impressionof a morphologically similar but unrelatedgranular cell tumour of the pituitary stalkIn contrast to most glioblastomas, the granular cell variant often shows immunoreactivityfor EMA. 12. Which of the following mutations are seen in diffuse midline gliomas? A. H3K27M B. EGFR C. IDH D. TERT Answer: A 13. Pilocytic astrocytomas occur commonly in which of the following locations in patients with neurofibromatosis type-1? A. Frontal lobe B. Thalamus C. Optic nerve D. Spinal cord Answer: C 14. True statement about pilomyxoid astrocytoma are all except? A. Has a monophasic architecture B. Has a predominant myxoid background C. Angiocentric pattern is very rare D. Rosenthal fibers and eosinophilic bodies are very rare Answer: C Explanation: In general, Pilomyxoid astrocytomas aremore aggressive and more prone to local recurrence and cerebrospinal spreadthan are pilocytic astrocytomas. Angiocentric pattern is characteristic of pilomyxoid astrocytomas. 15. Identify this tumor found in the in the intraventricular location? IDENTIFY THE TUMOR A. Ependymoma B. Sub ependymal giant cell astrocytoma C. Gemistocytic astrocytoma D. Giant cell glioblastoma Answer: D SEGA cells are larger than ependymomaGemistocytic astrocytoma have a intraparenchymal location as compared to intraventricular location. 16. What is the WHO grade of this tumor commonly arising from cauda equina, conus medullaris or filum terminale? Find the tumor A. Grade I B. Grade II C. Grade III D. Grade IV Answer: A Explanation: Myxopapillary ependymoma is grade I 17. All of the following are subtypes of ependymoma except? A. Clear cell B. Papillary C. Tancytic D. Giant cell Answer: D 18. All of the following are good prognostic markers of glioblastoma multiforme except? A. Age<50 years B. Secondary glioblastoma C. MGMT Promoter methylation D. Presence of necrosis Answer: D 19. The picture is from a tumor in a 10-year old male in the lateral ventricle-the tumor cells are CK7 positive and transthyretin positive. What is the diagnosis? IDENTIFY THE TUMOR A. RELA Fusion ependymoma B. Choroid plexus papilloma C. Astroblastoma D. Pleomorphic xanthoastrocytoma Answer: B Explanation: Chororoid plexus papillomas are CK7 and transthyretin positive. 20. Which of the following brain tumors show dot like positivity for EMA ? A. Medulloblastoma B. Ependymoma C. Diffuse astrocytoma D. Meningioma Answer: B Some illustrations on this topic you might be interested in CHOOSE TOPIC OF YOUR INTEREST TO READ ARTICLES FOR CHAPTERWISE MCQS ON OTHER TOPICS- VISIT HERE PARIS SYSTEM FOR REPORTING URINARY CYTOLOGY MCQs 22 Mar 202222 Mar 2022 Breast Pathology MCQ 1 12 Mar 202212 Mar 2022 CNS Pathology case based MCQs-2 23 Feb 202223 Feb 2022 New posts in your inbox Enter your email address Sign Up Let’s hang out Facebook Twitter LinkedIn Instagram YouTube Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...