BREAST PATHOLOGY – QUIZ Welcome to your BREAST PATHOLOGY - QUIZ 1. This tumor was recognized as a new entity in WHO 2019 classification? Identify Oncocytic carcinoma Tall cell carcinoma with reverse polarity PEComa Usual ductal hyperplasia 1 out of 20 2. Which of the following molecular abnormality is most common in tall cell carcinoma with reverse polarity of the breast IDH2 172 hotspot mutations TET2 ATM KIT 2 out of 20 3. False statements about fibroadenoma is? Add description here! Juvenile fibroadenoma generally occurs in younger and adolescent patients < 20 years; reported in children at a very young age Myxoid fibroadenoma is associated with carney complex 1.5 to 2 relative risk for breast cancer in juvenile fibroadenoma Relative risk is higher -3.1in complex fibroadenoma 3 out of 20 4. Most common mutations associated with usual- adult type fibroadenoma is? MED 11 MED 12 CDKN2A TP53 4 out of 20 5. Which of the following is true regarding variants of fibroadenoma? Myxoid fibroadenomas lack MED12 mutations Most common pattern in juvenile fibroadenoma is intracanalicular Juvenile fibroadenomas comprise of large cysts and calcifications Cellular fibroadenomas have a mitosis of >10/high power field 5 out of 20 6. Which of the following features is characteristic of malignant phylloides tumor? Mitotic count of > 5/ high power field Stromal hypercellularity Presence of a component of chondrosarcoma Necrosis 6 out of 20 7. Presence of which of the following malignant mesenchymal tumors does not upgrade a benign phylloides tumor to malignant? Angiosarcoma Rhabdomyosarcoma Leiomyosarcoma Well differentiated liposarcoma 7 out of 20 8. True statement about Zuska disease or periductal mastitis is? >90% individuals are smokers Non-keratinizing squamous epithelium extending into the nipple duct. Recurrent abscesses do not occur A relative deficiency of Vitamin C is associated with this disease 8 out of 20 9. All are markers of stromal cells of breast except? GCDFP-15 bcl2 Vimentin CD34 9 out of 20 10. Which of the following features is seen in metaplastic carcinoma but absent in phylloides tumor Positivity for CD34 and bcl2 Positivity for CK 5/6 Presence of bizzare atypical cells All of the above 10 out of 20 11. Which of the following immunohistochemical stains is used to differentiate the breast lesion shown in the picture from atypical ductal hyperplasia? CK 5/6 ER Her2 neu All of the above 11 out of 20 12. Which of the following features differentiate atypical ductal hyperplasia of breast and low grade carcinoma in situ? Size Number of lobules involves Both None 12 out of 20 13. The lesion shown in the picture is a clonal lesion , also known as columnar alteration with atypia. Which clonal abnormality is frequent in this lesion Deletion 17p Deletion 16q Deletion 13q Deletion 22q 13 out of 20 14. All are components of Van-nuys prognostic grading for DCIS except? Size of tumor Mitosis Age Margins 14 out of 20 15. An elderly female presented with crusting, elevated scaling erythematous rash in the skin of left breast. Biopsy from the lesion is shown below. All statements are true about the lesion except? CK7 is positive This tumor is hypothesised to arise from melanocytes GCDFP-15 is positive ER, PR and Her-2 neu positive in some cases. 15 out of 20 16. A 40- year old female was diagnosed with metastatic breast cancer based on clinical and radiological findings. A trucut biopsy was performed and sent by the surgeon. The surgeon requested for assessment of ER, PR and Her-2 neu status in order to proceed with therapeutic decision making. The tumor was ER and PR negative on Immunohistochemistry whereas positive controls tested positive. Her-2 neu IHC is shown in the image below. Correct statement regarding reporting Her-2-neu status is? A) Report as Her-2-neu positive based on IHC Perform In situ hybridization and report positive if > 6 copies of her-2 gene copies. C) Perform In situ hybridization and report positive if <2 (HER2 gene signals to chromosome 17 signals) are seen. D) Perform In situ hybridization and report positive if <4 copies of her-2 gene copies. 16 out of 20 17. Most common salivary gland type tumor of the breast is? Adenoid cystic Mucoepidermoid pleomorphic adenoma polymorphous low grade adenoma 17 out of 20 18. Which of the following is true regarding the molecular classification of breast carcinoma Lumina A type are ER, PR and Her 2 neu positive Luminal B type have a poor prognosis Triple negative tumors have a favorable outcome Luminal A is the commonest among all types 18 out of 20 19. Which of the following is false regarding the type of breast carcinoma shown in the picture? It has a favorable prognosis > 90% mucinous component is required for diagnosis of pure mucinous carcinoma Is usually triple negative Luminal A type 19 out of 20 20. If a ductal carcinoma of breast consists of 66℅ tubule formation with majority of the nuclei twice the size of normal ductal cells and amitotic count of 6/10 HPF. What is the modified vlbloom richardson grade and nottingham prognostic index 6 - moderately differentiated 4- well differentiated 7 - moderately differentiated 8 - poorly differentiated 20 out of 20 Please fill in the comment box below. Time is Up! Time's up Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...