Female genital tract pathology- (UTERUS and OVARY)

Quiz on- Ovarian tumors. Each correct answer carries 1 marks.

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What is the pTNM stage according to AJCC 8th edition of a malignant ovarian tumor. Both ovaries are involved and uterine implants are present. No nodal involvement or no other organ involvement is seen.

A. pT1c N0 M0, Stage IC

B. pT1c N0 M1b, Stage IVB

C. pT2a N0 M0 Stage IIB

D. pT3c N0 M1b, Stage IVB

Which of the following precursors is marked correctly with the type of ovarian cancer arising from it?

A. Serous borderline tumor- High grade serous carcinoma

B. Benign Brenner tumor- Mucinous carcinoma

C. Serous tubal intraepithelial carcinoma- Low grade serous carcinoma

D. All are true

Most common site of Serous tubal intraepithelial carcinoma (STIC) lesion is?

A.Fimbriae

B.Ampulla

C.Isthmus

D.None

Which of the following appearances of high grade serous carcinomas of ovary should raise suspicion and mandate testing for BRCA1 mutation

Solid

Mucinous

Clear cell

Papillary

Which of the following is genes is implicated in the progression of Serous borderline ovarian tumor to low grade serous carcinoma?

A. P53

B. RAS

C. ARIDA

D. BRCA

In which of the following ovarian epithelial tumors is trastuzumab tried as a therapy?

A. Mucinous

B. Transtional

C. Clear cell

D. Endometrioid

PARP- inhibitors are used in the therapy of which of the following ovarian epithelial tumors

Clear cell carcinoma

High grade serous ovarian epithelial tumors

Transitional cell tumors

Mucinous carcinoma

Which of the following tumors is shown in the picture? On IHC staining, it has FOX L2 and Inhibin positive. (Reticulin stain shown in the picture)

Add description here!

Granulosa cell tumor

Thecoma

Fibroma

Sertoli-leydig cell tumor

A 55- year old female presents with post menopausal bleeding. An endometrial tumor was identified (morphology in image. She had a history of ovarian tumor resection 2 years back. Which of the following options represent the ovarian tumor

Leydig cell tumor

Serous borderline tumor

Granulosa cell tumor

Chronic Endometriosis

20-year-old woman who presented with abnormal uterine bleeding and abdominal pain. An adnexal mass was identified and surgical excision was performed. Histopathology is shown in the picture. Which of the following is true regarding the tumor?

A. FOXL-2 mutations is present in majority of cases

B. 50% tumors are bilateral

C. Inhibin is a useful marker to differentiate this tumor from thecomas.

D. Inhibin negative tumors are also calretinin negative

Choriocarcinoma does NOT react immunohistochemically with which of the following?

A. Inhibin

B. hCG

C. Human placental lactogen

D. Pancytokeratin

The finding shown in the picture is characteristic of which ovarian tumor?

Leydig cell tumor

Sertoli cell tumor

Granulosa cell tumors

Fibroma

What differentiates a malignant Brenner tumor from an ovarian transitional cell tumor?

A. History of a primary bladder tumor

B. Mucinous metaplasia

C. Presence of malignant components of transitional cells alone without benign or borderline components

D. All of the above

All of the following are associated with Peutz- Jehers syndrome except?

A) Sertoli cell tumors

B) Adenoma malignum

C) Sertoli leydig cell tumor with annular tubules (STCAT)

D) Brenner tumor

True regarding the ovarian tumor shown in the picture is?

A. Does not have a favorable prognosis

B. Presence of severe atypia

C. Presence of epithelial cells in sheets

D. Presence of psammoma bodies in atleast >75% papillae in the rest

Mixed malignant germ cell tumors of ovary are most commonly composed of which of the following components

A. Dysgerminoma and yolk sac tumor

B. Yolk sac tumor and embryonal carcinoma

C. Dysgerminoma and embryonal carcinoma

D. None of the above

Identify the grade of teratoma, if the tumor contains moderate embryonal neural tissue >1 to < 4 low power fields?

Grade I

Grade II

Grade III

Immature neural tissue is not important in the grading of teratoma

Which of the following laboratory parameters are increased in this tumor

AFP

CA-125

hCG

PLAP

A 40 - year old female presented with lower abdominal pain. On CT a right ovarian mass, the mass was excised, an H and E stained section is shown below. Which of the following is true regarding this tumor?

A) Serum hCG and AFP are elevated in all tumors

B) They are typically negative for CD30, SOX2, and glypican-3

C) OCT3/4 and glypican -3 are positive on IHC

D) Granulomatous reaction is present in 100% of cases

Germline truncating mutations in which of the following have been reported in sertoli and leydig cell tumor?

TP53

DICER1

KRAS

BRAF

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