Robbins general pathology mcqs- with answers General pathology quiz- with answers General pathology quiz from chapters 1 to 4. Please wait for the answers to appear after selection. Do leave your Feedback. 1. Identify the true statement regarding satellite DNA It is a major component of telomeres It is important in maintaining the organization of heterochromatin It consists of very small arrays All of the above 1 out of 25 2. Which of the following statements is true regarding epigenetic modifications is false? A) DNA methylation leads to transcriptional silencing. B) Lysine residues are acetylated by histone acetylases which lead to repression of transcription. C) Epigenetic modifications are often reversible D) Chromatin organizing factors are thought to regulate promoters and enhancers that control gene expression. 2 out of 25 3. Which of the following statements regarding DNA variation is false? 90% of SNP ( Single nucleotide polymorphisms) occur in the coding region Almost 50% of CNV ( Copy number variations) occur in the coding region. SNP's are almost always biallelic SNP's are usually co- inherited with the disease associated polymorphism. 3 out of 25 4. A 40 year old male was diagnosed with cuteneous T-cell lymphoma, a drug which inhibits histone acetylase was used for the treatment. Which of the following drugs were used? Cyclosporine Vorinostat Methotrexate Rituximab 4 out of 25 5. Which of the following statements about gene editing technology is false? Cas9 is a dual RNA guided DNA endonuclease enzyme. Streptococcus pyogenes adaptive immunity utilizes CRISPR-Cas9. ZFN ( Zinc finger nucleases) were the first available gene editing technology. CRISPR stands for- Controlled Repeatedly Interspaced Short Palindromic Repeats. 5 out of 25 6. Which of the following phospholipids usually present inside the cell membrane, when exposed can result in cell death? Phosphatidylinositol Phosphatidylserine Sphingomyelin Ceramides 6 out of 25 7. A 3 month old child presents with failure to thrive, coarse facial features and abnormal skeletal development since birth. This condition was identified to be caused due to deficiency in a enzyme which phosphorylayed mannose residues. What is the diagnosis? I cell disease Hurlers syndrome Pseudo hurler dystrophy Mucopolysacchradosis type 1 7 out of 25 8. Identify the false statement regarding reversible cell injury. Generalized cell swelling Fatty change Increased basophilia of cells Accumulation of myelin figures 8 out of 25 9. Renal arteries from a 39 year old female showed the findings in the picture on post mortem. She had a history of hypertension and cause of death was renal failure. Which of the following conditions did she suffer from? Tuberculosis Polyarteritis nodosa Septic shock Renal artery stenosis 9 out of 25 10. All of the following disorders are caused by defective or misfolded proteins except? Parkinson disease Familial hypercholesterolemia Cystic fibrosis Alzheimer's disease 10 out of 25 11. Increased production of which of the following cytokines is common to chronic inflammation, atrophy and cancer? IL-1 TGF -beta TNF alpha IL-12 11 out of 25 12. All of the following features are seen in ageing cells except? Shortened telomeres Activation of TP53 Increased autophagy Increased length of telomeres. 12 out of 25 13. A 40-year-old woman comes to her physician after noticing a 3-cm firm irregular mass in her right breast. A subsequent biopsy of this mass reveals chronic inflammation, necrotic adipose tissue with saponification, and areas of calcification. These histologic findings are consistent with the diagnosis of: Breast cancer Granulomatous mastitis Fat necrosis Acute mastitis 13 out of 25 14. Which of the following facilitates leucocyte migration through endothelium? LFA-1 E-selectin MAC-1 CD 31 14 out of 25 15. Which of the following is true regarding neutrophil extracellular traps (NETs) ? Macrophages are responsible for the formation of NETs They are the major defence mechanisms against viruses The extracellular traps consist of a viscous meshwork of nuclear chromatin that binds and concentrates granule proteins such as antimicrobial peptides and enzymes Usually cells involved in the process are preserved 15 out of 25 16. Identify the anti-inflammatory cytokine among the following TNF-alpha TGF-beta IL-12 IL--4 16 out of 25 17. 29. A 23-year-old woman nursing her newborn develops a tender red area around the nipple of her left breast. The painful site of the patient's affected breast is primarily due to which of the folliowing mediators Bradykinin, Histamine and PGE2 IL-1 and TNF - alpha C3a and C5a PGF2 and PG D2 17 out of 25 18. In a thrombus, the dark lines of zahn are due to Coagulated fibrin Aggregated proteins Aggregated platelets Aggregated RBCs 18 out of 25 19. In the mononuclear phagocyte system which is true? Chemotactic stimuli for monocytes include C5a and certain growth factors Monocytes transform into smaller macrophages when they reach extravascular tissue Half life of blood monocytesis about 1 month Aggregation of macrophages in kidney is known as Kupffer cells 19 out of 25 20. Identify the correct match C-X-C chemokines- eotaxin C-C chemokine- Lymphotaxin C chemokine- IL-8 CX3C chemokine- Fractalkaline 20 out of 25 21. A 4-year old boy presented with intermittent episodes of mucosal bleeding. Further testing revealed that he had a defect in platelet aggregation. Which of the following is deficient in this patient? Gp Ib/IX vWF GpIIb/IIIa Factor VIII deficiency 21 out of 25 22. 31. Which of the following clotting factor effects may result in thrombosis instead of bleeding? Factor VIII Factor IX Factor X Factor XII 22 out of 25 23. A 35 year old female returned from a 12 hour flight journey. She suddenly developed loss of consciousness. She was diagnosed with cerebral stroke. Which of the following underlying conditions could be identified in this patient? Pulmonary wedge thrombis Ventricular septal defect Renal calculus Berry's aneurysm 23 out of 25 24. Which of the following plays a role in hemostasis, in preventing expansion of clot: Endothelin Prostacyclin Tissue factor T-PA (tissue plasminogen activator) 24 out of 25 25. These are acidophilic bodies seen in acute and chronic hepatitis. Which of the following is the reason for deep eosinophilic staining? Excess mitochondria Loss of endoplasmic reticulum Excess lysosomes Excess protein deposition. 25 out of 25 Please fill in the comment box below. Time is Up! Time's up Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...