GI PATH QUICK Quick ANSWERS

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A 52-year-old female is diagnosed with autoimmune gastritis during an evaluation for pernicious anemia. Which of the following statements is true regarding this condition?

A) Antibodies to H. Pylori are present

B) Can transform to type I carcinoid

C) Gastrin production is markedly decreased

D) Most commonly occurs in the gastric antrum

E) Antibodies to intrinsic factor are absent

None

A 60-year-old male with a history of chronic gastric conditions is being evaluated for potential gastric adenocarcinoma risk. Which of the following conditions does NOT result in gastric adenocarcinoma?

A) Menetrier disease

B) Gastric adenomas

C) Gastritis cystica

D) Autoimmune gastritis

E) Chronic H. Pylori infection

None

A 45-year-old male with a family history of polyposis syndromes is found to have multiple colonic polyps. Genetic testing reveals MUTYH-related polyposis. Which statement is false regarding this condition?

A) APC gene is involved in the pathogenesis

B) Fewer polyps are present compared to familial adenomatous polyposis

C) Colon cancer development is later in onset compared to familial adenomatous polyposis

D) It is an Autosomal recessive syndrome

E) Associated with biallelic MUTYH mutations

None

A 50-year-old patient with chronic gastritis undergoes biopsy. The pathologist uses the Sydney system for classification of gastritis. Which of the following morphological features is NOT graded in this system?

A) Atrophy

B) Inflammation

C) Intestinal metaplasia

D) Presence of granulomas

E) Lymphocytic infiltration

None

A 38-year-old male presents with a history of polyposis syndromes. Genetic testing suggests does not suggest any significant genetic disturbance. Which of the following hereditary polyposis syndromes is NOT inherited in an autosomal dominant fashion?

A) Familial adenomatous polyposis

B) Turcot syndrome

C) Cronkchite Canada syndrome

D) Cowden syndrome

E) Lynch syndrome

None

A 55-year-old patient is diagnosed with sporadic colon cancer during a routine colonoscopy. Which of the following genes is most commonly mutated in sporadic colon cancer?

A) MLH1

B) APC

C) MSH2

D) BRAF

E) KRAS

None

A 43-year-old female presents with chronic diarrhea, abdominal pain, and weight loss. A biopsy reveals colonic inflammation. Which of the following histologic features is NOT characteristic of ulcerative colitis?

A) Presence of pseudopolyps

B) Presence of multiple strictutes

C) Pseudopyloric epithelial metaplasia

D) Inflammation limited to the superficial mucosa and submucosa

E) Crypt abscesses

None

A 32-year-old female is diagnosed with a gastrointestinal stromal tumor (GIST) that shows loss of succinate dehydrogenase (SDH) staining. Which of the following statements about SDH-deficient GIST is FALSE?

A) Has a female preponderance

B) Strong immunoreactivity for SDHB

C) Exclusively occurs in the stomach

D) Affects young adult population

E) Commonly associated with germline SDH mutations

None

A 45-year-old patient with a newly diagnosed gastrointestinal stromal tumor (GIST) is being evaluated for prognostic factors. Which of the following statements is FALSE regarding the prognostic factors of GIST?

A) Gastric GIST has a better prognosis.

B) Tumor rupture is also with a worse outcome

C) Kit exon 11 mutation is imatinib resistant

D) Tumor size > 10 cm is associated with a worse outcome.

E) Mitotic rate is an important prognostic factor

None

10.

A 39-year-old female is diagnosed with a rare gastric tumor suspected to be a clear cell sarcoma. Which gene mutation is commonly associated with gastric clear cell sarcoma?

A) FLT3

B) STAT3

C) SMAD2

D) EWSR1

E) MALAT1-GLI1

None

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