INI-SS Hematopathology mock test -02

Welcome to your INI-SS Hematopathology mock test -02

Preferably attempt the test on a tablet or PC for an exam like experience

Quiz consists of 80 questions, general+hematopathology

Correct answer carries 1 POINTS and Wrong answer carries -1/3 points (DM/INI-SS Pattern)

QUIZ DURATION IS- 90 minutes

Which of the following is responsible for an increased incidence of cancer in old age?

Deselect Answer

A) Telomerase reactivation

B) Loss of telomeres

C) Telomerase deactivation

D) Excess shortening of telomeres

None

Which of the following is false regarding sirtuins?

Deselect Answer

A. Reduce apoptosis

B. Reduce insulin sensitivity

C. Stimulate protein folding

D. Increased by caloric restriction

None

Which of the following mode of inheritances is seen in Ehler-Danlos syndrome?

1. Autosomal dominant
2. Autosomal recessive
3. Mitochondrial
4. X-linked recessive
5. Genomic imprintingDeselect Answer

A) 2, 3, and 4

B) 1 only

C) 1, 2, and 4

D) 1.3, and 5

None

Which of the following traits are examples of co-dominance inheritance?

1. ABO blood group
2. Hair colour
3. Height
4. Skin color
5. HLADeselect Answer

A) 2. 3 and 4 only

B) 1. 2 and 4 only

C) 1 and 5 only

D) 3. 4 and 5 only

None

A 4-year-old boy is brought to the pediatrician with delayed developmental milestones. He has history of violently biting and chewing fingernails. Laboratory reports reveal hyperuricemia. What is the mode of inheritance in this condition?

Deselect Answer

A) Autosomal dominant

B) Autosomal recessive

C) X-linked dominant

D) X-linked recessive

None

T-cell receptors, when coexpressed with CD8 molecules, are restricted to recognizing and binding peptide fragments associated with

Deselect Answer

A. CD3 molecules.

B. CD4 molecules.

C. MHC class I molecules.

D. MHC class II molecules.

None

A 38-year-old man underwent excision of a lipoma. The swelling had been excised with a clear linear incision and was sutured cleanly. In this wound, when would you expect peak neovascularization?

Deselect Answer

A) Day 4

B) Day 3

C) Day 5

D) Dav 7

None

A 39-year-old woman is being evaluated for anemia. She is a known case of rheumatoid arthritis. Increased levels of which of the following is responsible for her anemia?

Deselect Answer

A) Fibrinogen

B) CRP

C) SAA

D) Hepcidin

None

Which of the following is not an angiogenesis promoter in tumor cells?

Deselect Answer

A) Thrombospondin

B) Interleukin-8

C) Epidermal growth factor

D) Angiogenin

None

Which of the following IHC pattern favours LCH?

Deselect Answer

A. S100+ve,CD1a +ve, Langerin +ve

B. S100 -ve, CD68 +ve

C. S100 -ve,CD1a -ve, Langerin -ve

D.S100 +ve, CD1a -ve, Langerin -ve

None

Which of the following is a CXC chemokine?

Deselect Answer

A) IL-8

B) RANTES

C) Lymphotactin

D) Fractalkine

None

Which of the following molecular abnormality is most common in tall cell carcinoma with reverse polarity of the breast

Deselect Answer

IDH2 172 hotspot mutations

TET2

ATM

KIT

None

Which of the following membrane bound inclusions are seen in motor neuron disease?

Deselect Answer

A. Red neurons

B. Bunina bodies

C. Hirano bodies

D. Pick bodies

None

5. An elderly woman with a history of loss of appetite and weight loss underwent a work up, which revealed carcinoma of caecum and deranged liver function due to hepatic metastases. What abnormalities can you expect?

Deselect Answer

A. High ALP

B. Low albumin

C. High AFP

D. A and B

E. A, B, C

None

Which of the following is involved in inducing the migration of leukocytes to sites of injury?

Deselect Answer

A) C5a

B) C3b

C) C3a

D) C5b

None

Pattern recognition receptors bind to?

Deselect Answer

A. B and T lymphocytes.

B. MHC I molecules.

C. Natural killer cells.

D. Pathogen-associated molecular patterns.

None

Maltese cross crystals in the urine are seen in which of the following diseases other than nephrotic syndrome?

Deselect Answer

A) Friedrich's ataxia

B) Felty syndrome

C) Fanconi anemia

D) Fabry's disease

None

A 26-year-old female patient is diagnosed with an astrocytoma. In childhood, she also suffered from osteosarcoma. Her family history is notable for several cancers in her maternal lineage, including both breast and brain tumors in her mother. Which of the following is the most likely underlying problem?

Deselect Answer

A. Li-Fraumeni syndrome

B. Neurofibromatosis 1

C. Retinoblastoma

D. Multiple endocrine neoplasia type 1

None

Which of the following is not a type of multiple sclerosis?

Deselect Answer

A. Relapsing-remitting

B. Primary progressive

C. Secondary progressive

D. Intermittent progressive

None

Which of the following connects the flow of cerebrospinal fluid (CSF) from the lateral ventricles to the third ventricle?

Deselect Answer

A.Foramen of Luschka

B. Foramen of Monro

C. Cerebral aqueduct

D. Fourth ventricle

None

Which disease is associated with multinucleated globoid cells on brain biopsy?

Deselect Answer

A. Niemann-Pick disease

B. Canavan disease

C. Krabbe disease

D. Fabry disease

None

Which of the following tumors is most commonly associated with opsoclonus-myoclonus?

Deselect Answer

A. Neuroblastoma

B. Medulloblastoma

C. Juvenile pilocytic astrocytoma

D. Ependymoma

None

Substance P is a peptide neurotransmitter involved in which of the following?

Deselect Answer

A. Muscle contraction

B. Circadian rhythm

C. Pain perception

D. Sweat production

None

1. Pattern recognition receptors bind to?

Deselect Answer

A. B and T lymphocytes.

B. MHC I molecules.

C. Natural killer cells.

D. Pathogen-associated molecular patterns.

None

2. In an individual with an immediate hypersensitivity response (allergy) to dust mites, cross-linking of which of the following dust-mite-specific molecules will trigger inflammatory mediator release?

Deselect Answer

A. Histamine

B. lgA

C. lgE

D. lgG

None

4.A 2-year-old child exposed to an antigen for the first time already possesses a B cell with immunoglobulin specific for that antigen. This finding is best explained by

Deselect Answer

A. Antigen-independent immunoglobulin gene rearrangements.

B. Antigen stimulation of T cell cytokine production.

C. Maternally derived antibodies to that antigen.

D. Memory B cells that recognize the antigen.

None

3. T-cell receptors, when coexpressed with CD8 molecules, are restricted to recognizing and binding peptide fragments associated with

Deselect Answer

A. CD3 molecules.

B. CD4 molecules.

C. MHC class I molecules.

D. MHC class II molecules.

None

A 40- year old female presented to the emergency with fatigue for 1 week and heavy nosebleed for the past few hours. CBC - Hb- 7.5g/dl WBC- 50 x 109 per liter Platelet count - 10,000 per microliter Peripheral smear shows the finding in the image. Which of the following is false regarding this condition?

False about this condition?Deselect Answer

A. Most commonly associated with PML-RARA fusion detectable by in- situ hybridization.

B. FLT3-ITD mutations are also common with this morphology.

C. ZBTB16-RARA fusion carries a worse prognosis due to treatment resistance

D. STAT5B-RARA fusion also carries a worse prognosis due to treatment resistance.

None

Which of the following cells are negative for periodic acid schiff?

Deselect Answer

Neutrophils

Basophils

Monocytes

Lymphocytes

None

Which of the following statements is true regarding PAS staining in hematolymphoid cells?

Deselect Answer

Lymphoblasts are PAS -negative

Megakaryoblasts show fine granular PAS positivity

Neutrophils cannot be used as control for PAS since they are PAS negative

Erythroblasts show block positivity for PAS

None

A 45-year-old man presents to his primary care physician (PCP) with symptoms of fatigue and easy bruising. A complete blood count (CBC) reveals a white blood cell (WBC) count of 68, hemoglobin of 9.8, and platelet count of 23. The WBC differential reveals 83% circulating blasts with Auer rods present. Bone marrow biopsy is performed and confirms the diagnosis of acute myeloid leukemia (AML). The patient begins induction chemotherapy with anthracycline and cytarabine in a standard 3 + 7 fashion using daunorubicin 90 mg/m2. Human leukocyte antigen (HLA) typing is sent on admission and he is found to have a 10/10 HLA matched sibling. With which of the following findings would you more strongly consider consolidation therapy with high-dose cytarabine in first complete remission (CR1)?

Deselect Answer

A. Normal male karyotype, FLT3-ITD mutation positive

B. Cytogenetics revealing t(6;9)

C. Cytogenetics revealing t(8;21), c-KIT mutation negative

D. Monosomal karyotype

None

A 21-year-old woman completed multiagent chemotherapy including alkylating agents, etoposide, and radiation therapy for Ewing’s sarcoma 2 years ago. She has been free of disease since but on routine blood work she was noted to have a white blood cell (WBC) count of 42, hemoglobin of 9, and platelet count of 77. Bone marrow biopsy confirms the diagnosis of acute myeloid leukemia (AML). Which cytogenetic abnormality is she most likely to have?

Deselect Answer

A. 11q23 abnormality

B. t(8;21)

C. t(15;17)

D. Monosomy 7

None

A 57-year-old woman presents with an elevated white blood cell (WBC) count of 55,000/mcL, hemoglobin of 13.5 g/dL, and platelet count of 160,000/mcL. A peripheral flow cytometry is sent and reveals a monoclonal population of cells expressing CD5, CD20 (dim), CD19, and CD23. The cells were negative immunohistochemically for cyclin D1. Which of the following is not associated with a poorer prognosis in this diagnosis?

Deselect Answer

A. Deletion 17p

B. Deletion 11q

C. ZAP-70 expression greater than 20%

D. Mutated IgVH status

None

A 45-year-old gentleman presents to clinic for the first time with a new diagnosis of chronic lymphocytic leukemia (CLL). He feels well and denies any fevers, chills, night sweats, or weight loss. He was noted to have an elevated white blood cell (WBC) count of 40,000/mcL, and absolute lymphocyte count (ALC) of 35,000/mcL on routine bloodwork that was obtained during a routine physical exam 6 months ago. His WBC in clinic today is now 65,000/mcL with an absolute lymphocyte count of 59,000/mcL. Which of the following diagnostic tests would be appropriate to obtain for both prognostic and future therapeutic management?

Deselect Answer

A. IgVH mutation status

B. ZAP-70 expression

C. CLL fluorescence in situ hybridization (FISH)

D. CD38 expression by flow cytometry

None

In evaluation of megaloblastic anemia following results are obtained.

Serum vitamin B12 level = 150-300 pg/ml (Normal-boderline range)
Serum folate > 4 ng/mL (Normal range)
Methylmalonic acid level > 0.4 micromol/L (Increased)
Intrinsic factor blocking antibody - Negative
Serum gastrin level > 200 pg/mL (Increased)

The findings :-Deselect Answer

A. Excludes pernicious anemia

B. Consistent with pernicoius anemia

C. Diagnostic of pernicious anemia

D. None of these

None

Which one of the following groups has the highest risk for pernicious anemia?

Deselect Answer

A. Malnourished infants

B. Children during growth periods

C. Persons older than 60 years of age

D. Pregnant women

None

Lead poisoning is associated with:

Deselect Answer

A. Microcytic hypochromic anemia

B. Macrocytic anemia

C. Decreased levels of zinc protoporphyrin

D. Howell-Jolly bodies

None

Which of the following regarding Bombay blood group is false?

Deselect Answer

A. Lack of H, A and B antigen on RBCs

B. Lack of H, A and B substance in saliva

C. Lack of antigens of several blood group system

D. H, A and B antibody will always be present in serum

None

Very severe aplastic anemia is?

Deselect Answer

A. Neutrophils <0.2 X109/1V

B. Neutrophils <0.5 X 109/1 X

C. Neutrophils <0.8 X 109/1

D. Neutrophils <1.2X 109/l

None

Most important therapeutic intervention as as soon as the diagnosis of (thrombotic thrombocytopenic purpura) TP is established or even suspected.

Deselect Answer

A. IV Methylprednisolone

B. Rituximab

C. Therapeutic plamsa exchange

D. IV Methotrexate

None

Which of the following is an example of a protooncogene?

Deselect Answer

A. P53

B. RB1

C. MYC

D. BRCA1

None

Which of the following is the correct sequence of events in cellular division?

Deselect Answer

A. G0, S, G1, G2, M

B. G0, G1, G2, S, M

C. S, M, G2, G1, G0

D. G0, G1, S, G2, M

None

Which of the following cells can suppress the antitumor immune response?

Deselect Answer

A. Regulatory T-cells (Tregs)

B. CD8+ T lymphocytes

C. Myeloid-derived suppressor cells (MDSCs)

D. A and C

None

Which of the following is an anticytotoxic T-lymphocyte associated antigen-4 (CTLA-4) antibody?

Deselect Answer

A. Pembrolizumab

B. Nivolumab

C. Avelumab

D. Ipilimumab

None

. On which of the following cells is the CTLA-4 checkpoint receptor located?

Deselect Answer

A. B-cells

B. Neutrophils

C. Dendritic cells

D. T-cells

None

A 65-year-old female presented with a 2-month history of fatigue and easy bruising. She was noted to be pancy- topenic. This led to a bm biopsy that demonstrated 65% cellularity with multilineage dysplasia and 13% blasts. Karyotype showed −7, −5, +11, +8 in 20/20 metaphases. What mutation is likely to be found in this patient?

Deselect Answer

A. RUNX1

B. GATA2

C. ASXL1

D. TP53

None

A 55-year-old morbidly obese female underwent gastric bypass surgery a year ago. She has lost 30 pounds since her surgery. She reports her knee pain has significantly improved with weight loss. She tries to exercise on a dai- ly basis. However, for the last couple of months she gets tired and fatigued easily. She presents to her PCP and is noted have pallor on exam. CBC shows Hb = 8.8 g/dL with MCV = 88. She has mild leukopenia and normal platelets. Her peripheral blood smear is reviewed by the hematopathologist who reports dysplasia and recom- mends a bone marrow exam. Stool exam is negative for occult blood. Other than MDS, what can be causing dys- plasia in this patient?

Deselect Answer

A. Vitamin B12 excess

B. Zinc deficiency

C. Copper deficiency

D. Lead deficiency

None

A 55-year-old female presents to her PCP for an annual physical. Her complete blood profile shows leukocytosis = 60 K/mm3, Hb = 12.5 g/dL, and platelets = 450 K/mm3. The differential showed metamyelocytes, myelocytes, and basophilia at 5.0%. A bone marrow exam shows CML chronic phase with t(9;22). What is the most likely aberrant

Deselect Answer

A. P210 BCR/ABL

B. P190 BCR/ABL

C. P230 BCR/ABL

D. P290 BCR/ABL

None

A 35-year-old male presents with a 4-month history of pruritic rash that comes and goes. The rash mainly involves his upper back. He also reports shortness of breath with wheezing and diarrhea when the rash ap- pears. The rash improves with antihistamines. The pa- tient is concerned that he is developing new allergies despite not being exposed to new detergents, creams, lotions, or soaps. He has cut back on dairy products but with no improvement in diarrhea when it occurs. Work- up shows elevated serum tryptase levels. A bone mar- row exam is expected to show which of the following by flow cytometry:

Deselect Answer

A. CD117+, CD25−, CD2−

B. CD117+, CD25+, CD2+

C. CD117+, CD33+, MPO+

D. CD34+, CD33+, MPO+

None

An 80-year-old male presents to the emergency center feel- ing weak and tired for the past 2 weeks. On presentation, his WBC = 200 K/mm3, Hb = 10.1 g/dL, and platelets = 75 K/mm3. Peripheral blood differential shows marked neutrophilia without any circulating blasts or basophilia. On examination, the spleen is palpable 6 cm below the left costal margin and the liver edge is also palpable. A bone marrow biopsy demonstrates increased myeloid precur- sors with 3% blasts. There is no evidence of dysplasia. Cy- togenetics are negative for t(9;22). What is the most likely mutation to be found in this case?

Deselect Answer

A. SETBP1

B. CSF-3R

C. EZH2

D. TP53

None

A 67-year-old female is diagnosed with primary my- elofibrosis after she presented with a 1-month history of worsening fatigue, weight loss, anorexia, and left upper quadrant fullness. She was noted to be anemic and had 1% circulating blasts. Spleen is palpable 10 cm below the left costal margin. A bone marrow exam shows a fibrotic marrow with a complex karyotype. Workup is negative for JAK2V617F, MPL, and CALR. Prognosis of this patient is expected to be poor mainly due to?

Deselect Answer

A. Negative JAK2V617F

B. Negative CALR

C. Triple negative disease

D. Anemia

None

A 78-year-old female with TP53 mutated CLL diagnosed 1 year ago was treated with ibrutinib for 9 months. Patient unfortunately progressed with worsening lymphadenopa- thy. She has now been on idelalisib and rituximab for 2 months. She presents to the ER with 1-day history of wors- ening shortness of breath, dry cough, and fever. On pres- entation, she is noted to be hypoxic. CXR shows bilateral fluffy infiltrates. What is the most likely causative agent?

Deselect Answer

A. Mycoplasma pneumoniae

B. Legionella pneumophila

C. Pneumocystis jiroveci

D. Human immunodeficiency virus

None

A 62-year-old male was recently diagnosed with stage III, diffuse large B-cell lymphoma. He has evidence of nodal disease above and below the diaphragm without bone marrow involvement. He complains of abdominal bloat- ing, but otherwise feels well and is out of bed the entire day. His platelet count is 98 and hemoglobin is 13.4. His erythrocyte sedimentation rate is normal. According the international prognostic index (IPI), which of the follow- ing are not adverse prognostic factors?

Deselect Answer

A. Elevated LDH

B. Poor performance status

C. Low hemoglobin

D. Elevated erythrocyte sedimentation rate

None

In the revised International Staging System, high-risk cy- togenetic features include the following:

Deselect Answer

A. t(11;14), t(4;14), −13

B. t(4;14; t(14;20), −17p

C. t(4;14), t(14;16), −17p

D. t(8;14), t(11;14), −13

None

The mainstays of myeloma therapy are immunomodu- latory agents and proteasome inhibitors in combination with corticosteroids (dexamethasone). The proteasome inhibitors are reversible or irreversible, boron-based or epoxyketone-based. One of the main pathways of inhibi- tion is through which of following?

Deselect Answer

A. Bcl-2

B. C-myc

C. Nf-kappa B

D. CTLA 4

None

Which of the following is not a risk factor for progression in MGUS?

Deselect Answer

A. Size of the M protein

B. Type of the M protein

C. Age of the patient

D. Abnormal free light chain ratio

None

The criteria for the revised International Staging System includes the following parameters:

Deselect Answer

A. Beta-2 microglobulin, albumin, M component, skeletal survey

B. Beta-2 microglobulin, albumin, LDH, M component

C. Beta-2 microglobulin, albumin, metaphase karyotype, LDH

D. Beta-2 microglobulin, albumin, LDH, FISH

None

A 76-year-old woman presents with rapid onset of “bruis- es” as shown below. She is otherwise healthy except for hypertension and hyperlipidemia. She does not take any anticoagulants and does not recall any trauma. A physical exam shows the lesion (below), but there is an absence of lymphadenopathy. A complete blood count shows a nor- mal WBC, a platelet count of 120,000 K/μL, and an hgb of 9.9 g/dL. PT and PTT are normal. A metabolic panel is nor- mal, and lactate dehydrogenase is normal. A skin biopsy shows an infiltrate of medium-sized cells involving the der- mis and subcutaneous fat. Immunohistochemistry shows that the abnormal cells express CD4 and CD56. CD20 and CD30 are negative, and EBER is negative. The most likely diagnosis is:

Deselect Answer

A. Primary cutaneous anaplastic large cell lymphoma

B. Subcutaneous panniculitis–like T-cell lymphoma

C. Extranodal natural killer (NK)/T-cell lymphoma

D. Blastic plasmacytoid dendritic cell neoplasm

None

What is the main mechanism of graft-versus-leukemia ef- fect using donor lymphocyte infusion?

Deselect Answer

A. Increase in CD8+ cells that recognize target antigens on tumor cells

B. CD8+/CD4+T cells recognize target antigens on tumor cells

C. Enhancing the presence of killer inhibitory receptors (KIRs) recognized by donor NK cells

D. Increase in TCR repertoire diversity

None

A 42-year-old man reports mild nausea, appetite changes, loss of 2 lbs weight, and loose stools over the past 2 weeks. He underwent a matched related donor transplant for AML 45 days ago. He is taking tacrolimus 1 mg twice daily and MMF 1000 mg 3 times daily. His tacrolimus blood lev- els are 7 ng/mL. He has undetectable viral loads as of last week. His physical exam shows a mild erythematous mac- ular popular rash. He is applying hydrocortisone cream to the rash. He underwent an esophagogastroduodenoscopy (EGD)/sigmoidoscopy, which was unremarkable. Pathol- ogy from gastric and sigmoid colon biopsies show single cell apoptosis with crypt epithelium in the gastric fundus and destruction of single crypts and glands with apoptotic crypt abscesses in the sigmoid colon. What is the lead cause of his GI symptoms?

Deselect Answer

A. Acute GVHD

B. MMF side effect

C. Viral gastroenteritis

D. CMV reactivation

None

Platelet agglutination at low ristocetin concentrations suggests a pathological enhancement of the VWF-GPlb interaction, which is characteristic of:-

Deselect Answer

A. Type 2A VWD

B. Type 2B VWD

C. Type 2M VWD

D. Type 2N VWD

None

Bernard Soulier syndrome is characterized by all except:-

Deselect Answer

A. Low platelet count

B. Giant platelets

C. Aggregation with ristocetin

D. Has defect in GPIb/IX

None

All of the following can cause both arterial and venous thrombosis, except:

Deselect Answer

A. APLA syndrome

B. Hyper homocysteinema

C. Protein C deficiency

D. Polycythemia vera

None

Autosomal dominant hereditary spherocytosis is caused by

Deselect Answer

A. Ankyrin

B. Spectrin

C. Band -3

D. None

None

A 47-year-old male presents with raised, erythematous nodular rash on his arm. He just came back from a hiking trip in the Rocky Mountains a few weeks ago. He unfortunately got sick with fevers and joint pain during his trip, but was treated with antibiotics, although he does not remember the name of the antibiotic. He monotherapy, [VD], [RVD], notices that this rash has not resolved and underwent a biopsy, which revealed a cutaneous mucosa-associated lymphoid tissue (MALT) lymphoma. What infection is associated with his cutaneous MALT lymphoma?

Deselect Answer

A. Rickettsia rickettsii

B. Bartonella henselae

C. Trypanosoma brucei

D. Borrelia burgdorferi

None

A 69-year-old male presents with night sweats and weight loss. He is found to have diffuse lymphadenopathy above and below the diaphragm. He underdoes an excisional lymph node biopsy of an axillary node, which is consistent with diffuse large B-cell lymphoma. Which of the following tests are needed before considering initiating rituximab therapy?

Deselect Answer

A. Cytomegalovirus (CMV) serologies

B. Herpes simplex virus (HSV) serologies

C. Hepatitis B surface antigen, hepatitis B surface antibody

D. Respiratory virus panel

None

Which of the following peripheral T-cell lymphoma (PTCL) subtypes has the best prognosis?

Deselect Answer

A. Angioimmunoblastic T-cell lymphoma (AITL)

B. Anaplastic large cell lymphoma (ALCL), ALK(+)

C. Extranodal NK/T-cell lymphoma

D. ALCL, ALK(−)

None

47-year-old man presents with an elevated lymphocyte count and peripheral blood shows some cells with hyperlobated nuclei appearing like clovers. Which pathogen is typically associated with this peripheral T-cell lymphoma (PTCL) subtype?

Deselect Answer

A. Helicobacter pylori

B. Epstein–Barr virus (EBV)

C. Human T-cell leukemia virus type 1 (HTLV-1)

D. Cytomegalovirus (CMV)

None

A 60-year-old man presents with years of pruritus with large scattered pink/erythematous patches on his chest, back, upper arms, and thighs. Past biopsies have showed eczema and folliculitis, and topical treatments have not resulted in improvement. Repeat biopsy shows mononuclear cells with cerebriform nuclei in upper dermis and epidermal keratinocytes with intraepidermal aggregates forming microabscess-like structures. What is the most likely diagnosis?

Deselect Answer

A. Sézary syndrome

B. Atopic dermatitis

C. Psoriasis

D. Mycosis fungoides

None

A 68-year-old man develops joint pain and swelling, fatigue, shortness of breath, night sweats, lower extremity erythematous rash, and enlarged neck lymph nodes. Labs show a white blood cell count of 10 K/mcL with an absolute lymphocyte count of 0.5 K/mcL, hemoglobin of 6.5 g/dL, platelet count of 130 K/mcL, total bilirubin 4.5 mg/dL, and lactate dehydrogenase (LDH) >2 × the upper limit of normal. Chest x-ray shows bilateral pleural effusions. What is the most likely diagnosis?

Deselect Answer

A. Angioimmunoblastic T-cell lymphoma (AITL)

B. Mycosis fungoides

C. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)

D. Follicular lymphoma

None

A woman without a significant past medical history and only surgical history of bilateral breast implants presents with right-sided breast fullness. In addition to a primary breast carcinoma, which of the following is in the differential diagnosis

Deselect Answer

A. Angioimmunoblastic T-cell lymphoma (AITL)

B. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)

C. Metastatic disease

D. Anaplastic large cell lymphoma (ALCL), ALK(–)

None

A patient with history of delayed postoperative bleeding has a normal PT, APTT, TT, and fibrinogen. Which of the following deficiencies/conditions is the patient likely affected by?

Deselect Answer

A. Factor XIII deficiency

B. Vitamin C deficiency

C. Hemophilia C

D. VWD subtype 2N

None

What point of care (POC) assay may be used to assess fibrinolysis, while treating a patient with trauma-induced coagulopathy?

Deselect Answer

A. PT and APTT

B. Plasminogen activity assay

C. Thromboelastograph (TEG)

D. Plasminogen activator inhibitor-1 (PAI-1) assay

None

Bisphosphonates in multiple myeloma patients do which of the following?

Deselect Answer

A. Reduce skeletal-related events

B. Improve bone pain

C. Reduce risk of myeloma-related renal dysfunction

D. A and B

None

The hemostasis laboratory technologist performs a mixing study on a plasma specimen from a 13-year- old Caucasian female of European descent with complaints of easy bruising, menorrhagia, and frequent epistaxis. She has no signs of deep tissue or joint bleeding. Her results are provided as follows:

Of the following choices, which test should be performed next?Deselect Answer

A.lupus anticoagulant (LA) profile

B. Coagulation factor VIII activity

C. Coagulation factor XI activity

D. Coagulation factor XII activity

None

A patient being prepared for a valve replacement undergoes a platelet aggregometry test with the following results:

What is the most likely reason for these results?Deselect Answer

A. Storage pool disease

B. VWD

C. Bernard-Soulier syndrome

D. Aspirin or a nonsteroidal antiinflammatory drug (NSAID)

None

Which is the true statement

Deselect Answer

A) Rb gene is the key regulator of G2M cell cycle transition.

B) Rb is active in hypophospholylated state

C) MDM2 protein activates p53

D) p53 activation leads to cell cycle progression

None

Which of the following micro-organisms require a biosaftey level 4 protection?

Deselect Answer

A) Streptococcus

B) Yersenia

C) Small pox

D) Mycobacterium

None

CAR- T cell therapy true is?

Deselect Answer

A. Allogenic B- cells are used

B. Most common adverse reaction is cytokine release syndrome (CRS)

C. Erythrocytapheresis is performed to extract the donor cells.

D. Autologous T-cells are never used.

None

Which of the following is an example of a protooncogene?

Deselect Answer

A. P53

B. RB1

C. MYC

D. BRCA1

None

Deselect Answer

A. Elevated LDH

B. Poor performance status

C. Low hemoglobin

D. Elevated erythrocyte sedimentation rate

None

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