Lung, heart and mediastinal tumors quiz

Welcome to your Lung, heart and mediastinal tumors quiz

A 34-year-old male is diagnosed with a cardiac tumor. Histologic section is shown in the image.. Which of the following statements about this tumor is true?

A) Sporadic myxomas frequently show genetic alterations.

B) Most common location is the left ventricle.

C) Myxomas with GNAS1 mutations are associated with McCune-Albright syndrome.

D) Myxomas with GNAS1 mutations are associated with Carney’s complex.

E) Myxomas predominantly occur in the right atrium.

None

A 55-year-old patient is diagnosed with a carciac tumor on imaging studies, The tumor was resected and histopathologic image is shown below.. Where are these tumors most commonly located?

A) Ventricular surface of semilunar Valves

B) Right atrium

C) Left atrium

D) Interatrial septum

E) Right ventricle

None

A 25-year-old man presents with cough and hemoptysis. An endobronchial polypoid mass is found, showing glandular mucin-secreting, intermediate, and squamous cells with low mitotic activity and no necrosis. What is the diagnosis?

A. Adenocarcinoma

B. Mucous gland adenoma

C. Adenoid cystic carcinoma

D. Low-grade mucoepidermoid carcinoma

E. Squamous cell carcinoma

None

A 63-year-old woman with a lung mass showing acinar growth and mucinous cells on biopsy is likely to have which mutation?

A. ALK rearrangement

B. BRAF

C. EGFR

D. KRAS

E. HER2

None

A 45-year-old non-smoker presents with a lung mass, and biopsy shows features of a carcinoid tumor. Which finding favors atypical carcinoid over typical carcinoid?

A. Negative p40

B. Positive TTF-1

C. Necrosis

D. No smoking history

E. Low mitotic rate

None

A 60-year-old patient is suspected of having sarcomatoid malignant mesothelioma. Which feature does NOT help distinguish it from reactive pleural fibrosis?

A. Foci of obvious malignant features

B. Invasion of the chest wall

C. Necrosis

D. Invasion of the lungs characterized by invasion of the alveolar septa

E. Nuclear atypia

None

A 65-year-old male with a large lung mass undergoes CT-guided fine-needle aspiration. Smears show sheets of epithelioid cells with well-defined borders and intercellular "windows." What is the most likely diagnosis?

A. Benign mesothelial cells

B. Well-differentiated adenocarcinoma of the lung

C. Benign bronchial epithelium

D. Mesothelioma

E. Small cell carcinoma

None

A biopsy of a lung mass shows epithelioid cells. Which panel of immune markers is most useful for differentiating mesothelioma from lung adenocarcinoma?

A. Calretinin, CK7, TTF, BerEP4, and CEA

B. Desmin, D2-40, WT1, CK7, TTF, BerEP4, and CEA

C. Calretinin, p53, WT1, TTF, BerEP4, CEA, and CD15

D. P63, p53, WT1, TTF, BerEP4, CEA, and CD15

E. MOC-31, CK5/6, EMA, and CA125

None

Which statement is NOT correct regarding KRAS mutations in lung cancer?

A. The KRAS protein stimulates downstream activity of EGFR tyrosine kinase.

B. KRAS mutations lead to constitutive activation of the RAS signaling pathway.

C. EGFR tyrosine kinase inhibitors (TKIs) cannot block the activity of mutated KRAS proteins.

D. KRAS mutations are more likely to be found in non-smokers.

E. KRAS mutations lead to impaired GTPase activity.

None

10.

Which of the following statements is true regarding STAS (Spread Through Air Spaces)

A. Randomly spread in airspaces from the tumor edge to the distant airspace tumor cells.

B. Occurs only as clusters or nests

C. Occur as linear strips of cells that are lifted off alveolar walls

D. Associated with increased recurrent rates in stage 1 adenocarcinomas

None

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