Lung, heart and mediastinal tumors quiz Posted on 16 Jul 2021 by pathologymcqs Welcome to your Lung, heart and mediastinal tumors quiz 1. True statement regarding myxomas is?A. Sporadic myxomas show genetic alterationsB. Most common location is the left ventricleC. Myxomas with GNAS 1 mutations have association with Mc cune albright syndromeD. Myxomas with GNAS1 mutations have association with Carney's complex 2. Papillary fibroelastomas are most commonly located inA. Ventricular surface of semilunar ValvesB. Right atriumC. Left atriumD. Interatrial septum 3. A 25-year-old man presents with cough and hemoptysis and is found to have an endobronchial polypoid mass. Histologically, the lesion consists of an admixture of glandular mucin-secreting cells, intermediate cells, and squamous cells. Mitotic activity and nuclear pleomorphism are sparse. There is no evidence of necrosis. The diagnosis is:A. AdenocarcinomaB. Mucous gland adenomaC. Adenoid cystic carcinomaD. Low-grade mucoepidermoid carcinoma 4. Which of the following immunostains can be used to differentiate pulmonary blastoma from carcinosarcoma?A. EGFRB. beta cateninC. RASD. MYC 5. A 63 year old woman presented with mass in the upper lobe of her left lung with enlargement of the mediastinal lymph nodes. Surgical biopsy shows columnar tumor cells with abundant intracytoplasmic mucin in an acinar growth pattern. The malignant cells are most likely to be positive for which of the following mutations?A. ALK rearrangementB. BRAFC. EGFRD. KRAS 6. Which of the following findings favour atypical carcinoid over typical carcinoidA. Negative p40B. Ki67 index 30%C. No necrosisD. No smoking history 7. The desmoplastic form of sarcomatoid malignant mesothelioma can be difficult to distinguish from reactive pleural fibrosis. All of the following features are helpful EXCEPT:A. Foci of obvious malignant featuresB. Invasion of the chest wallC. NecrosisD. Invasion of the lungs characterized by invasion of the alveolar septa 8. A transthoracic CT-guided fi ne-needle aspiration is performed on a 65-year-old male who has a large right lower lobe lung mass. Sheets of relatively uniform epithelioid cells with well defi ned cell borders and intercellular “windows” are identifi ed on aspiration smears. What is the most likely diagnosis?A. Benign mesothelial cellsB. Well-differentiated adenocarcinoma of the lungC. Benign bronchial epitheliumD. Mesothelioma 9.Which panel of immune markers is most useful for the differential diagnosis of mesothelioma and lung adenocarcinoma?A. Calretinin, CK7, TTF, BerEP4, and CEAB. Desmin, D2-40, WT1, CK7, TTF, BerEP4, and CEAC. Calretinin, p53, WT1, TTF, BerEP4, CEA, and CD15D. P63, p53, WT1, TTF, BerEP4, CEA, and CD15 10. All of following cytological features can be seen in a small cell carcinoma of the lung, EXCEPT:A. The size of tumor cells are two- to threefold of mature lymphocytesB. Paranuclear blue bodies in the cytoplasmC. Nuclear crowding and moldingD. Prominent nucleoli 11. Which of the following statements is NOT correct?A. The KRAS protein stimulates downstream activity of EGFR tyrosine kinase.B. KRAS mutations lead to a constitutive activation of RAS signaling pathway.C. EGFR tyrosine kinase inhibitors (TKIs) cannot block the activity of mutated KRAS proteins.D. KRAS mutations are more likely to be found in non-smokers. 12. Which of the following features favour thymic carcinoma over thymoma?A. Association with myasthenia gravisB. Uninvaded surroungong tissueC. Jigsaw puzzle like pattern with presence of immature T cellsD. Monomorphic epithelial cells with atypia and pleomorphism often showing immunoreactivity for CD117 Time is Up! Time's up Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading... Related Author: pathologymcqs Daily MCQ's and updates will be posted for various entrance exams View All Posts
