MSI- Testing - PATHOLOGY MCQs

Welcome to your MSI- Testing

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1.

Which of the following mutations is LEAST likely to be associated with MSI-H colorectal cancer?

a) MLH1 promoter hypermethylation

b) BRAF V600E mutation

c) KRAS mutation

d) MSH2 germline mutation

2.

Which of the following histological features is MOST suggestive of MSI-H colorectal cancer?

a) Extensive necrosis with pseudopalisading cells

b) Well-differentiated glandular structures

c) Signet-ring cell morphology

d) Prominent intraepithelial lymphocytes

3.

Which of the following features best differentiates Lynch-like syndrome (LLS) from classical Lynch syndrome?

a) Tumor MSI-H status

b) Loss of MMR protein expression on IHC

c) Absence of a germline mutation in MMR genes

d) Right-sided location of tumors