NIFTP - questions - PATHOLOGY MCQs

Welcome to your NIFTP - questions

Which of the following findings would most strongly suggest a diagnosis of NIFTP over classic FVPTC?

a) A predominantly follicular architecture with pseudoinclusions

b) A RAS mutation with encapsulation and no invasion

c) A BRAF V600E mutation with nuclear grooves and pseudoinclusions

d) A solid/trabecular growth pattern with necrosis and high mitotic activity

None

NIFTP lesions are typically categorized under which Bethesda classification category during fine needle aspiration (FNA) cytology?

a) Category II: Benign

b) Category III: Atypia of Undetermined Significance (AUS)

c) Category V: Suspicious for Malignancy

d) Category VI: Malignant

None

In NIFTP, which of the following architectural patterns, if dominant, would require exclusion of the diagnosis?

a) Microfollicular growth pattern

b) Trabecular or solid growth pattern

c) Predominant follicular growth pattern

d) Scattered true papillae within a follicular background

None

In cases of NIFTP, what is the typical management approach following lobectomy, assuming no high-risk features are identified?

a) Completion thyroidectomy with radioactive iodine ablation

b) Observation without further surgical or adjuvant treatment

c) Lifelong suppressive levothyroxine therapy

d) External beam radiation therapy

None

Which of the following scenarios represents the most common pitfall in diagnosing NIFTP on FNA cytology?

a) Presence of microcalcifications leading to a mistaken diagnosis of classic PTC

b) Identification of isolated nuclear inclusions suggesting conventional PTC

c) Predominant follicular architecture with mild nuclear atypia categorized as AUS or FLUS

d) Presence of a solid growth pattern with high cellularity leading to overdiagnosis of malignancy

None

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