A 60-year-old male presents with a mass in the kidney that, on electron microscopy, shows numerous cytoplasmic microvesicles in pale cells and abundant mitochondria in eosinophilic cells. What is the most likely diagnosis based on these findings?

A 45-year-old woman with a history of sickle cell trait is diagnosed with an aggressive renal tumor located in the medulla. Immunohistochemistry reveals loss of INI1 expression. What is the most likely diagnosis?

A 55-year-old male presents with a kidney tumor. A biopsy reveals a tubular growth pattern with medullary involvement and desmoplastic stroma. The tumor is cytologically high-grade and shows infiltrative growth. What is the most likely diagnosis?

A 16-year-old female presents with an incidental right renal mass. The patient undergoes a radical nephrectomy. The tumor is well encapsulated, with unilocular cystic lesions, grey-brown solid areas, and hemorrhagic foci. Microscopic analysis reveals clear cells, and immunohistochemistry shows CK7-, CD10+, and Cathepsin K+ staining. What is the likely diagnosis?

A 70-year-old male presents with a renal mass incidentally discovered on imaging. A core biopsy is performed, and the histological examination reveals a well- circumscribed tumor composed of cells with abundant eosinophilic granular cytoplasm and round, centrally located nuclei. Immunohistochemistry (IHC) shows the following: CD117: Negative CK7: Positive S100A1: Positive CD10: Negative MITF (Microphthalmia Transcription Factor): Positive MDM2: Negative FH (Fumarate Hydratase): Retained expression Based on the histological and IHC findings, which of the following is the most likely diagnosis?

A 50-year-old male with a history of hematuria undergoes nephrectomy. Gross examination reveals a large mass originating in the renal pelvis and extending into the ureter. What is the most likely diagnosis?

A 50-year-old female presents with a painless hematuria. Imaging reveals a mass in the kidney. A biopsy shows a papillary growth pattern with foamy macrophages and psammoma bodies. What is the most likely diagnosis?

A 62-year-old woman with a history of smoking presents with hematuria and flank pain. Imaging reveals a renal mass. Histopathology shows nests of tumor cells with eosinophilic cytoplasm surrounded by a prominent desmoplastic stroma. What is the most likely diagnosis?

Which of the following genetic alterations is incorrectly matched with its associated renal tumor?

You receive a radical nephrectomy specimen containing a necrotic tumor measuring 8 cm in size, confined to the kidney. The tumor does not involve any major veins. What is the most likely pathological stage of the tumor?