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Robbins pathology chapter 1 mcq- The cell

Welcome to your Robbins chapter 1- The cell

All of the following are part of functional non-protein coding sequences except?

Non-coding regulatory RNA

Promoter and Enhancer regions

Exons

Centromere

True statement about histone organization are all except?

Histone subunits are negatively charged

Nucleosomes are comprised of octamers of histone proteins encircled by 1.8 147 bp DNA loops

Euchromatin is transcriptionally active

Histone acetylation opens up the chromatin

True about CRISPR/Cas9 system except?

High precision gene editing system

Non-homologous end joining is better than homologous end joining to repair DNA breaks.

Cas9 is a dual RNA guided DNA endonuclease enzyme.

CRISPR stands for- Clustered regularly interspaced short palindromic repeats.

Which of the following is not matched correctly?

Lysosome- Autophagy

Endosomal vescicles- shuttle internalized materials outside the cell

Proteosome- Degrades tagged proteins

Peroxisomes- Breaks down very long chain fatty acids.

Most abundant cytoskeletal protein, 5-9 nm in diameter is

Actin

Myosin

Desmin

Laminin

All are true regarding protein synthesis except?

Membrane bound ribosomes in the RER translate mRNA.

Chaperones assist folding of proteins

From the RER, proteins and lipids destined for other organelles or extracellular export are shuttled into the Golgi apparatus

O- linked oligosaccharides are converted into N- linked Oligosaccharides in golgi apparatus.

All are true about receptors with tyrosine kinase activity except?

Downstream phosphorylation is a common pathway of signal transduction

Changes in receptor geometry can stimulate intrinsic receptor protein kinase activity

The cellular homologue of the transforming protein of the Rous sarcoma virus, called Src, is the prototype of this family.

Which one is matched correctly?

Add description here!

EGFR- synonymous to ERB-B2

Her-2-neu -ERB-B1

TGF-beta- Inflammatory cytokine

Hepatocyte growth factor- Scatter factor.

Which of the following is false about collagen ?

Collagen I,V and XI are heterotrimers

Marfan syndrome is caused by defects in collagen

Helix formation occurs in the golgi apparatus

Cross-linking occurs in the extracellular space

Correctly matched with organ and stem cell niche are all except?

Intestine- crypts

Eyes- limbus of cornea

Brain- periventricular zones

Bone marrow- Paratrabecular area

Which is the true statement?

Rb gene is the key regulator of G2M cell cycle transition.

Rb is active in hypophospholylated state

MDM2 protein activates p53

p53 activation leads to cell cycle progression

1 out of 11

Time’s up

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Posted

2 May 2021

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Pathology MCQs

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4 responses to “Robbins pathology chapter 1 mcq- The cell”

Dr. Tarun Roy

19 Nov 2022

Hepatocyte growth factor is also known as scatter factor.
Ref: https://en.wikipedia.org/wiki/Hepatocyte_growth_factor

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Pathology MCQs

19 Nov 2022

Yes that is correct!!

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Aashish K

30 Dec 2022

Q3 should be ‘All are true EXCEPT’ i suppose

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1. Pathology MCQs
  
  30 Dec 2022
  
  Yes, that’s right!! Corrected.
  
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