Robbins pathology chapter 1 mcq- The cell - PATHOLOGY MCQs

Welcome to your Robbins chapter 1- The cell

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All of the following are part of functional non-protein coding sequences except?

A. Non-coding regulatory RNA

B. Promoter and Enhancer regions

C. Exons

D. Centromere

None

True statement about histone organization are all except?

A. Histone subunits are negatively charged

B. Nucleosomes are comprised of octamers of histone proteins encircled by 1.8 147 bp DNA loops

C. Euchromatin is transcriptionally active

D. Histone acetylation opens up the chromatin

None

True about CRISPR/Cas9 system except?

A. High precision gene editing system

B. Non-homologous end joining is better than homologous end joining to repair DNA breaks.

C. Cas9 is a dual RNA guided DNA endonuclease enzyme.

D. CRISPR stands for- Clustered regularly interspaced short palindromic repeats.

None

Which of the following is not matched correctly?

A. Lysosome- Autophagy

B. Endosomal vescicles- shuttle internalized materials outside the cell

C. Proteosome- Degrades tagged proteins

D. Peroxisomes- Breaks down very long chain fatty acids.

None

Most abundant cytoskeletal protein, 5-9 nm in diameter is

A. Actin

B. Myosin

C. Desmin

D. Laminin

None

All are true regarding protein synthesis except?

A. Membrane bound ribosomes in the RER translate mRNA.

B. Chaperones assist folding of proteins

C. From the RER, proteins and lipids destined for other organelles or extracellular export are shuttled into the Golgi apparatus

D. O- linked oligosaccharides are converted into N- linked Oligosaccharides in golgi apparatus.

None

All are true about receptors with tyrosine kinase activity except?

A. Downstream phosphorylation is a common pathway of signal transduction

B. Changes in receptor geometry can stimulate intrinsic receptor protein kinase activity

C. The cellular homologue of the transforming protein of the Rous sarcoma virus, called Src, is the prototype of this family.

None

Which one is matched correctly?

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A. EGFR- synonymous to ERB-B2

B. Her-2-neu -ERB-B1

C. TGF-beta- Inflammatory cytokine

D. Hepatocyte growth factor- Scatter factor.

None

Which of the following is false about collagen ?

A. Collagen I,V and XI are heterotrimers

B. Marfan syndrome is caused by defects in collagen

C. Helix formation occurs in the golgi apparatus

D. Cross-linking occurs in the extracellular space

None

10.

Correctly matched with organ and stem cell niche are all except?

A. Intestine- crypts

B. Eyes- limbus of cornea

C. Brain- periventricular zones

D. Bone marrow- Paratrabecular area

None

11.

Which is the true statement?

A. Rb gene is the key regulator of G2M cell cycle transition.

B. Rb is active in hypophospholylated state

C. MDM2 protein activates p53

D. p53 activation leads to cell cycle progression

None

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