Robbins Chapter 2 MCQs - PATHOLOGY MCQs

Welcome to your Robbins Chapter 2 MCQs- Cell injury, death and adaptations

1.

A- 68-year -old woman suddenly lost consciousness; on awakening I hour later, she could not speak or move her right arm and leg. Two months later, a head CT scan showed a large cystic area in the left parietal lobe. Which of the following pathologic processes has most ikely occurred in the brain?

Deselect Answer

Fat Necrosis

Coagulative Necrosis

Apoptosis

Liquefactive Necrosis

Karyolysis

2.

In an experiment, cells are subjected to radiant energy in the form of X-rays. This results in cell injury caused by hydrolysis of water. Which of the following cellular enzymes protects the cells from this type of injury:

Deselect Answer

Phospholipase

Glutathione peroxidase

Endonuclease

Lactate dehydrogenase

Protease

3.

Enzymes involved in the inactivation of free radicals include:

Deselect Answer

Phospholipase A

Catalase

Both A and B

Neither A nor B

4.

A decrease in organ size (atrophy) may be a result of each of the following except:

Deselect Answer

Lack of innervations

Reduction of blood supply

Aging

Metabolic storage disease

Reduction of hormonal stimulation

5.

Following injury, which tissue restores functional capacity by hypertrophy:

Deselect Answer

Liver

Skin

Cardiac Muscle

Adrenal cortex

6.

Which of the following is an example of physiologic apoptosis?

Deselect Answer

Cell death due to radiation damage

Reduced cell proliferation by apoptosis of receptors to maintain homeostasis

Cell death due to infectious process

Cell death triggered by accumulation of misfolded proteins

7.

Which is not a morphologic feature of apoptosis?

Deselect Answer

Cell shrinkage and increased eosinophilia

Cytoplasmic blebbing and apoptosis bodies

Chromatin condensation

Presence of acute and chronic inflammatory infiltrate

8.

Which pair is matched correctly?

Deselect Answer

BH3 only proteins- inhibitors of apoptosis

BH1-3 proteins- trigger apoptosis

BH1-4 proteins- Inhibitors of apoptosis

Intrinsic pathway- activates caspases 8 and 10

9.

True about necroptosis are all except?

Deselect Answer

Activation is similar to the extrinsic pathway of apoptosis

Both physiological and pathological necroptosis can occur

It is a caspase independent pathway of cell death

PUMA and NOXA are regulators of necroptosis

10.

True about pyroptosis is?

Deselect Answer

It is a form of apoptosis accompanied by the release of IL-1

Similar to apoptosis no inflammation is involved

Caspase 8 initiates cell death

None of the above

11.

False statement about autophagy?

Deselect Answer

LC3 is a marker of autophagy

Neurodegenerative diseases can occur as a result of dysregulation of autophagy

This is a distinct pathway, different from both necrosis and apoptosis

Exercise, fasting and ageing inhibits autophagy

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