Pathology MCQs for various entrance exams

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1. Which of the following enzymatic changes are characteristic of neurotization?

A. Loss of tyrosinase and acquisition of acetylcholine

B. Loss of acetylcholine and acquisition of tyrosinase

C. Loss of acetylcholine and acquisition of catecholamines

D. Loss of tyrosine and acquisition of catecholamines

2. True regarding dysplastic nevus syndrome is?

A. This lesion does not progress to melanoma

B. Has Autosomal recessive mode of inheritance

C. The probability of transformation to melanoma in dysplastic nevus syndrome is 50 % by the age of 60

D. The probability of transformation to melanoma in sporadic dysplastic nevii is is 50 % by the age of 60

3. Activating mutations in FGFR 3 is seen in which of the following?

A. Actinic keratosis

B. Seborrheic keratosis

C. Cylindroma

D. Syringoma

4. A 20-year-old female presents with bilateral malar rash in a butterfly distribution and signs of acute pleuritis. A skin biopsy shows liquefactive degeneration of the basal cell layer, variable epidermal atrophy, perivascular and periadnexal lymphocytic infiltration, and a thickened basement membrane. Which of the following patterns of immunofluorescence would be expected?

A. Deposits of IgA at the tips of dermal papillae

B. Granular deposits of IgG and C3 along the dermal–epidermal junction

C. Intercellular IgG deposition within the epidermis

D. Linear deposition of IgG and C3 along the dermal–epidermal junction

5. True about Hailey – Hailey disease except?

A. Inherited in autosomal dominant manner

B. Associated with mutations in the ATP2C1 gene

C. Immunofluorescence shows fish net epidermal IgG and C3 deposits

D. Predominantly suprabasal bullae is seen

6. Which of the following basal cell carcinoma are associated with an increased risk of recurrence?

A. Nodular

B. Pigmented

C. Superficial

D. Micronodular

7. Which of the following viruses have been found recently in association with keratoacanthomas?

A. Human polyoma virus 6

B. Human herpes virus 8

C. Varicella zoster virus

D. Cytomegalo virus

8. A 50- year- old man presents with a one- year history of several large flat, erythematous lesions on his back and groin. Which of the following would be most suggestive of mycosis fungoides?

A. Presence of similar lesions on the face and bilateral arms

B. Presence of ulceration

C. Detection of widespread lymphadenopathy

D. Detection of several raised, indurated lesions in the same area

9. According to the pathway concept of melanoma classification, which of the following melanomas arise in sun – sheilded skin?

A. Desmoplastic melanoma

B. Lentigo maligna

C. Superficial spreading melanoma

D. Uveal melanoma

10. Which of the following mutations are not seen in Uveal melanomas?

A. GNAQ

B. BRAF

C. GNA11

D. BAP 1

SKIN PATHOLOGY QUIZ

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SKIN PATHOLOGY QUIZ

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