Pathology MCQs for various entrance exams

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Welcome to SOFT TISSUE AND BONE TUMORS QUIZ

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1. Which of the following soft tissue tumors is excluded from the TNM staging?

Liposarcoma

Chondrosarcoma

Angiosarcoma

Fibrosarcoma

2. Which of the following chromosome deletions is associated with spindle cell/pleomorphic lipoma?

Deletion 13q14

Deletion 8q11

Deletion 15p13

Deletion 11p19

3. Which of the following cytogenetic alterations are seen in myxoid liposarcoma?

t(11;22)

t(12;15)

t(12;16)

t(9;22)

4. All of the following statements is true regarding nodular fascitis except?

Composed of plump spindle shaped cells

A well defined capsule is present

Neoplastic cells express SMA (Smooth muscle actin) and MSA (Myosin specific actin) in a typical tram track pattern

In cellular areas, there is often growth in S-shaped or C-shaped fascicles, or sometimes in a storiform pattern.

5.Which of the following statements is true regarding the tumor shown in the picture?

Has no association with NF2

Aggressive tumor

Diffuse staining for SOX10 and S100 is present

Recurrence is common even after excision

6.Identify the false statement regarding chondromyxoid fibroma?

Recombinationof the GRM gene has a role in the pathogenesis

Multinucleated giant cells are frequent in the cellular areas

Mitosis is infrequent

It is an aggressive tumor having poor prognosis

7. Which of the following findings favour telangiectatic osteosarcoma over aneurysmal bone cyst?

Presence of atypia

Presence of hemorrhage

Giant cells clustered around the area of hemorrhage

All of the above

8. Undifferentiated round cell sarcomas show all of the following genetic abnormality except?

EWSR1

MYC

CIC1

BCOR

9.Which of the following findings favour epithelioid hemangioendothelioma over epithelioid hemangioma

Abundant eosinophilc infiltrates

Presence of FOS or FOS B rearrangements

Presence of hyalinized stroma

All of the above

10. Identify the false statement regarding synovial sarcoma?

Driven by the chromosomal translocation t(X;18)(p11;q11) involving genes SS18 and either SSX1, SSX2 or SSX4

Biphasic tumor

SOX 10 and CD 34 positive

Positive for Bcl2, cytokeratins and CD99

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SOFT TISSUE TUMORS QUIZ- pathology board questions

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