Von willebrand disease – MCQs

Welcome to your Von willebrand disease - MCQs

1. A laboratory technologist performs a VWD profile on a specimen from a 23-year-old male who complains of easy bruising and frequent epistaxis. His results are as follows:
Vwd lab findings
Based on these results and the clinical history, what is the most likely diagnosis for this patient?
2. What is a common initial therapeutic option for Type 1 VWD?
3. A patient appears to have type 2 VWD because the VWF:RCo to VWF:Ag ratio is <0.7. The laboratory technologist performs the ristocetin-induced platelet agglutination (RIPA) assay using customary (1.0 mg/mL) and reduced ristocetin concentrations: 0.5, 0.25, and 0.1 mg/mL, respectively, a procedure called the ristocetin response curve. The technologist observes platelet agglutination at all concentrations of ristocetin. What VWD subtype is most likely based on these results?
4. An 18-year-old man with a history of von Willebrand disease (vWD) is scheduled to undergo wisdom-tooth extraction. In preparation for his procedure, his hematologist is planning to perform a trial of desmopressin (DDAVP) to see whether he responds. In which one of the following types of von Willebrand disease has DDAVP been known to cause thrombocytopenia?
5. A 20-year-old woman with a history of menorrhagia was recently diagnosed with vWD. Her laboratory results showed markedly reduced factor VIII levels with normal vWF antigen levels and normal multimetic pattern. Which one of the following types of vWD is most consistent?