Tag: Acute leukemias
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Periodic acid schiff (PAS) staining patterns in hematopoietic cells
Different hematopoetic cells stain differently with PAS stain. Let’s look at various PAS staining patterns in hematopoietic cells. 1. MYELOID PRECURSORS AND NEUTROPHILSMyeloid precursors show diffuse PAS positivityNeutrophils show intense granular positivity 2.MONOCYTES AND THEIR PRECURSORSMonocytes and their precursors show variable diffuse positivity. 3.ERYTHROID PRECURSORS AND RED BLOOD CELLS (RBCs)Red blood cells are PAS negativeErythroblasts…
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6 KEY POINTS TO REMEMBER IN ACUTE LYMPHOCYTIC LEUKEMIA (ALL) – t(5;14)
6 KEY POINTS TO REMEMBER FOR BOARDS – ACUTE LYMPHOCYTIC LEKUKEMIA- t(5;14) Basts harbour a translocation between IL3 and an IGH gene, resulting in variable eosinophilia This diagnosis can be made on the basis of immunophenotypic and genetic findings even if the bone marrow blast count is low. patients may present with an asymptomatic eosinophilia,…
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5 Differences between hyper granular (M3) and microgranular (M3v) variants of acute promyelocytic leukemia ( APML)
Differences between hypergranular (M3) and microgranular (M3v) variants of acute promyelocytic leukemia ( APML) Acute Promyelocytic leukemia is an unique syndrome different from other forms of acute myeloid leukemia (AML). From clinical symptoms such as disseminated intravascular coagulation (DIC) to unique chromosomal translocation – t(15;17) the list is endless. Acute promyelocytic leukemia has two common…
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10 Key points to remember in NPM-1 mutated AML (Acute myeloid leukemia)
Acute myeloid leukaemia (AML) with mutated NPM1 carries mutations that usually involve exon 12 of NPM1. Here are some key points to remember. 1. There is a female predominance in this type of AML. 2. There is a strong association between both acute myelomonocytic and acute monocytic leukaemia and NPM1 muÂtation. 3. Charactistic cup-shaped blasts…