Robbins pathologic basis of disease 10th edition updates Robbins pathologic basis of disease 10th edition has a handful of changes and updates when compared to it’s predecessor. Here is a brief note on the chapterwise general pathology updates which are high yield for entrance exams. ROBBINS 10TH EDITION CHAPTERWISE UPDATES CHAPTER 1- CELL Satellite DNA– A major component of centromeres is so-called satellite DNA, consisting of large arrays—up to megabases in length—of repeating sequences (from 5 bp up to 5 kb). Although classically associated with spindle apparatus attachment, satellite DNA is also important in maintaining the dense, tightly packed organization of heterochromatin.Gene Editing and CRISPR- An exciting new development that allows high-fidelity genome editing may usher in the next era of the molecular revolution. This advance comes from a wholly unexpected source: the discovery of clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated genes (Cas), such as the Cas9 nuclease. Crispr/ cas9 system update Robbins 10 th edition CHAPTER 2- ADAPTATIONS AND INJURY Ferroptosis- Only discovered in 2012, ferroptosis is a distinct form of cell death that is triggered when excessive intracellular levels of iron or reactive oxygen species overwhelm the glutathione-dependent antioxidant defenses. CHAPTER 3-INFLAMMATION AND REPAIR Neutrophil extracellular traps (NETs)– NETs were mentioned in the previous edition it is further elaborated in the latest edition. Neutrophil extracellular traps (NETs) are extracellular fibrillar networks that concentrate antimicrobial substances at sites of infection and trap microbes, helping to prevent their spread. CHAPTER 6- IMMUNITY Rejection of tissue transplants: Elaborated compared to the previous edition. CHAPTER 7- NEOPLASIA A few newly added proto-oncogenes: FMS-like tyrosine kinase 3 (FLT3) Point mutation or small duplications in Leukemia.GTP-binding (G) proteins- GNAQ Point mutation in Uveal melanoma.GTP-binding (G) proteins- GNAS Point mutation in Pituitary adenoma. A few newly added tumor suppessor genes: SDHB, SDHD (Succinate dehydrogenase complex subunits B and D TCA cycle, oxidative phosphorylation) seen in Familial paraganglioma, familial pheochromocytoma. Elaboration of oncogenic activities of E6 an E7 proteins of human papilloma virus (HPV) Human papilloma virus update Robbins pathology 10th edition In the older edition it was mentioned that the E6 protein of HPV inactivates p53. In the 10th edition it is mentioned that in addition to inactivation of p53, E6 protein also increases telomerase expression (TERT). CHAPTER 8- INFECTIOUS DISEASES Updates on the SARSCoV2 virus Click here for general pathology quiz Click here for general pathology blogs PARIS SYSTEM FOR REPORTING URINARY CYTOLOGY MCQs by Pathology MCQs 22 Mar 2022 Breast Pathology MCQ 1 by Pathology MCQs 12 Mar 2022 CNS Pathology case based MCQs-2 by Pathology MCQs 23 Feb 2022 Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Differences between the types of human DNA variations General Pathology Topics The two most common forms of human DNA variation in the human genome 1. Single nucleotide polymorphisms (SNPs) and 2. Copy number variations (CNVs). Let’s looks at a few differences between the two human DNA variations. Very important topic for examinations. Single nucleotide polymorphisms (SNVs) SNPs are variants at single nucleotide positions and are almost always biallelic. Roughly 1% of SNPs occur in coding regions. SNPs may be useful markers if they happen to be coinherited with a disease-associated polymorphism. In other words, the SNP and the causative genetic factor are in linkage disequilibrium. Copy number variations CNVs can be biallelic and simply duplicated or,deleted in some individuals.Approximately 50% of CNVs involve coding sequences.CNVs are responsible for 5 million and 24 million base pairs of sequence difference between any two individuals. Click below for questions on the related topics MCQ’S GENERAL PATHOLOGY-GENOME (26/03/2021) Click below for a quick summary CNS Pathology case based MCQs-1 by Pathology MCQs 22 Feb 2022 Central nervous system pathology MCQ 1 by Pathology MCQs 13 Feb 2022 Characteristics of Epithelial-Mesenchymal transition by Pathology MCQs 7 Dec 2021 Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
BLACK FUNGUS WHITE FUNGUS AND YELLOW FUNGUS. What is the black, white and yellow fungus COVID -19 second wave and journalism in India have introduced us to Black, white and yellow fungus. What are these originally? Let’s decode some terminilogy. Before delving in let’s look at ways to differentiate two major opportunistic infections in COVID-19 patients based on morphology- MUCOR and ASPERGILLUS. 1. BLACK FUNGUS What is being referred to as black fungus? Mucor is being referred to as the black fungus. Is the fungus itself black in colour? No, in a setting of immunosuppression, mucor grows rapidly causing angioinvasion and tissue necrosis. This results in a blackish appearance of the affected area, giving rise to the name. What is the real black fungus? Dermataceous fungi Some fungii have excess melanin, also called melanized or dermaticious fungi. They are the real black fungi. Moreover, presence of melanin is not uncommon in Histoplasma spp, Aspergillus spp (especially Aspergillus niger) and even candida spp. 2. WHITE FUNGUS What is being referred to as white fungus? White patches in candida Candida albicans. This fungus has the tendency to produce patchy white coloured lesions, hence the name. 3. YELLOW FUNGUS What is being referred to as yellow fungus? Mucor septicus. This fungus has not been associated with any human infections till now. It’s identification is still a mystery. What is the real yellow fungus? Aspergillus in culture central blackish pigment and peripheral yellow to white Aspergillus– When cultured, aspergillus has a blackish center due to the melanin, and whitish or yellowish body. Actinomycetes has a unique feature, pus in this infection has a yellow color due to the presence of sulfur granules. That’s it for now! Thank you. Click here for review question For Morphologic differences between Mucor and aspergillus check this out! For more articles RB-1 DELETED SOFT TISSUE TUMORS by Pathology MCQs 6 Dec 2021 SALIVARY GLAND PATHOLOGY QUIZ by Pathology MCQs 16 Nov 2021 THYROID PATHOLOGY QUIZ by Pathology MCQs 26 Oct 2021 Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...