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Tag: FRCPath part 1 histopathology
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Important molecular markers of non small cell lung carcinoma
Frequency of gene mutations in non-small lung carcinoma Majority of mutations comprise of EGFR, RAS and ALK Summary of molecular markers of non-small cell carcinoma and therapeutic targets Reference Reference 1 and Reference 2 Some MCQs related to this topic
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MUCINOUS NEOPLASMS OF THE APPENDIX
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Tumors showing TRK (tropomyosin receptor kinase) gene fusion
Recent molecular studies have revealed that, several tumors harbor TRK fusion. However fusion frequencies vary. Several NTRK1/2/3 (neurotrophic tyrosine receptor kinase) fusions have been reported. It is important to identify them since they serve as potential targets for therapy The NTRK1, 2, and 3 genes encode a family of tyrosine kinase receptors with an active…
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6 KEY POINTS FOR BOARDS – MICROPAPILLARY BREAST CARCINOMA
Micropapillary breast carcinoma is a rare variant. Micropapillary carcinoma of breast has a few unique clinical, microscopic and immunological features which aid in their differentiation from other subtypes of breast carcinoma. Let’s look at them!! 1. Tufts of cells arranged in pseudopapillae ( lack fibrovascular cores). These pseudopapillae are surrounded by empty clear spaces formed…