Differences between Kimura disease and Angiolymphoid hyperplasia with eosinophilia Kimura disease and Angiolymphoid hyperplasia with eosinophilia (ALHE) are often confused and need to be differentiated. Here are a few differences. 1.AGE Kimura’s disease is a chronic inflammatory condition of unknown cause that affects young to middle-aged patients, most often males of Asian descent. Whereas, ALHE is more common in females. 2.LOCATION Kimura disease patients usually have a mass in the head and neck region with involvement of subcutaneous tissue, soft tissue, salivary glands, and single or multiple regional lymph nodes. ALHE also commonly involves the head and neck region, particularly behind the ears. 3.HISTOLOGY Key histologic features of kimura disease includes florid follicular hyperplasia that may contain a proteinaceous precipitate (IgE in a follicular dendritic network pattern) and vascularization of the germinal centers. The interfollicular areas show prominent high endothelial venules with a mixture of lymphocytes, plasma cells, eosinophils, and mast cells. Follicle lysis is often present, and eosinophilic abscesses are characteristic within germinal centers as well as in the paracortex. ALHE on the other hand, is a vascular neoplasm characterized by the proliferation of blood vessels lined by plump endothelial cells with abundant eosinophilic cytoplasm, imparting a hobnail appearance. This lesion is part of the spectrum of what have been called histiocytoid or epithelioid hemangiomas, and is a low-grade vascular tumor. There is a dense, mixed inflammatory cell infiltrate consisting of lymphocytes, plasma cells, and eosinophils. 4. IMMUNOHISTOCHEMISTRY Reticular pattern of IgE is seen in KIMURA disease. However, immunohistochemistry in ALHE is positive for CD 31, CD 34 and Factor VIII in the vascular component. 5.PERIPHERAL BLOOD EOSINOPHILIA Peripheral blood examination shows eosinophilia and increased serum IgE levels in kimura disease but not so much in ALHE. FIND A QUICK SUMMARY BELOW REVIEW QUESTION 1. A 20- year- old Asian male has eosinophilia and high levels of IgE with cervical lymphadenopathy. Excisional biopsy of the lymph node demonstrates follicular hyperplasia, intense eosinophilia and eosinophilic microabscesses. h e most likely diagnosis is: A. Kimura disease B. Kikuchi- Fujimoto disease C. Eosinophilic leukemia D. Hypereosinophilic syndrome CLICK TO REVEAL ANSWER Answer is A- Kimura disease like Kikuchi disease is seen more ot en in the Asian population. h e etiology is not known. h is is a chronic inl ammatory disorder of the subcutaneous tissue and af ects regional lymph nodes. h e cervical area is the most common site to be involved. Histology of the af ected lymph nodes demonstrates follicular hyperplasia, eosinophilia with eosinophilic microabscesses and ini ltration of the germinal centers. Increase in vessels may also be seen. Warthin Finkeldey giant cells may also be present. 2. All are true about kimura disease except A. Affects asians B. Affects females C. Peripheral eosinophilia is present D. Elevated levels of IgE are seen CLICK HERE TO REVEAL ANSWER Answer is B- Kimura disease is more common in males. Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
SICKLE CELL ANEMIA MCQs How good is your hematology knowledge? Answer these questions on sickle cell anemia and test your knowledge. Useful for FRCPath Hematology, NEET-SS clinical hematology and Hematology boards. START QUIZ You may join telegram channel- Pathology mcqs For pathology mcqs, quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq For more questions related to transfusion medicine VISIT HERE For hematology quizzes and blogs. VISIT HERE Test your knowledge QUIZ- Hematology Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
INHERITED PLATELET DISORDERS -QUIZ Useful for Hematology boardsFRCPath HematologyDM Hematology (NEET-SS) DM HematopathologyHematopathology fellowships Find illustration on platelet granule disorders START INHERITED PLATELET DISORDERS QUIZ HEMOSTASIS AND COAGULATION Quiz OTHER HEMATOLOGY QUIZZES AND BLOGS TRANSFUSION MEDICINE QUIZZES You may join telegram channel for more questions- Pathology mcqs For pathology mcqs, quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Clinical hematology practice MCQS- Part 2 How good is your hematology knowledge? Answer these questions and test your knowledge. Useful for FRCPath Hematology, NEET-SS clinical hematology and Hematology boards. START QUIZ You may join telegram channel- Pathology mcqs For pathology mcqs, quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq For more questions related to transfusion medicine VISIT HERE For hematology quizzes and blogs. VISIT HERE Test your knowledge QUIZ- Hematology Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
HEMOSTASIS AND THROMBOSIS -QUIZ Useful for Hematology boardsFRCPath HematologyDM Hematology (NEET-SS) DM HematopathologyHematopathology fellowships SHORT QUIZ ON HEMOSTASIS AND THROMBOSIS LONG HEMOSTASIS AND COAGULATION Quiz OTHER HEMATOLOGY QUIZZES AND BLOGS TRANSFUSION MEDICINE QUIZZES You may join telegram channel for more questions- Pathology mcqs For pathology mcqs, quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...