Molecular pathology of ADIPOCYTIC TUMORS Molecular pathology of ADIPOCYTIC TUMORS – based on WHO 2020 Soft tissue and bone tumors. LIPOMAS The pathogenesis of lipomas is related to reactivated expression of the HMGA2 protein, which plays a role in the development of the mesodermal lineage during embryogenesis ANGIOLIPOMA– The majority (80%) have been reported to have low-frequency PRKD2 mutations. CHONDROID LIPOMA– is characterized by a recurrent t(11;16) (q13;p13) chromosomal translocation.SPINDLE CELL/PLEOMORPHIC LIPOMA: is characterized 13q deletions /RB GENE.MYOLIPOMA: Cytogenetic alterations of the HMGA2 gene have been reported in a few cases LIPOSARCOMA Atypical lipomatous tumour/well differentiated liposarcoma: characterized by supernumerary ring and giant marker chromosomes,containing amplified sequence of MDM2DEDIFFERENTIATED liposarcoma– Amplified MDM2MYXOID LIPOSARCOMA– Translocations producing FUS-DDIT3 or rarely EWSR1-DDIT3 fusion transcripts are pathognomonicPLEOMORPHIC LIPOSARCOMA: Complex karyotypes. . The most frequent mutations involve TP53 and NF1. OTHER ADIPOCYTIC TUMORS HIBERNOMA: Cytogenetically, almost all hibernomas have breakpoints in chromosome arm 11q, with a distinctive clustering to 11q13.LIPOBLASTOMA: The most common numerical change is one or more extra copies of chromosome 8, with or without concurrent rearrangement of 8q11-q13 VIEW THE SHORT VIDEO FOR A QUICK SUMMARY View this post on Instagram A post shared by Pathology Mcqs (@pathology_mcqs) Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...