Difference between type I and type II endometrial carcinoma TYPE I AND TYPE II ENDOMETRIAL CANCER—Endometrial carcinomas can be divided into two groups based on epidemiologic,clinical, morphologic, and genetic features: TYPE I ENDOMETRIAL CANCER Younger patients: 40 to 60 years History of hyperestrinism, for example, chronic anovulation,estrogen replacement therapy.Associated with endometrial hyperplasia Grade I, nonmyoinvasive endometrioid carcinomas, usual type or main variants.ER–PR immunoreactivity Low Ki-67 labeling index Microsatellite instability, PTEN mutations, no p53 mutations Immunoreactivity of stromal cells for CD10 Favorable prognosis following hysterectomy TYPE II ENDOMETRIAL CANCER Older patients: 60 to 80 yearsNo previous hyperestrinism Atrophic endometriumOften associated with a high-grade in situ lesion Grade III tumors, often of special types (serous, clear cell types), Lack of ER–PR p53 mutations, no microsatellite instabilityUnfavorable prognosis following hysterectomy Type I Endometrial carcinomaType II Endometrial carcinomaMorphologic types: ENDOMETRIOID CARCINOMAMorphologic types: SEROUS AND CLEAR CELL CARCINOMADifference between type I and type II endometrial carcinoma For similar articles click here For summary visit below You may join telegram channel- Pathology mcqs For pathology mcqs, quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq Liked the page? Why not leave a tip for it’s creators Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...