Posted in Female genital pathology, Histopathology, Molecular pathology

Molecular pathogenesis of ovarian epithelial tumors.

Molecular progression of serous ovarian tumor. Borderline low and high grade

1.Molecular progression of low grade ovarian serous tumors.
There is data to suggest progression from serous cystadenoma / cystadenofibroma with BRAF / KRAS mutations → SBT (serous borderline tumor) → LGSC (Low grade serous carcinoma) ; however, this is still controversial

2. Molecular progression of high grade serous ovarian tumors.

TP53 alterations in nearly all cases of high grade serous carcinoma

Germline, somatic or promoter hypermethylation (inactivation) of BRCA1 and BRCA2 in ~50% of cases

Posted in General pathology, Robbins questions

GENERAL PATHOLOGY MCQ- IRREVERSIBLE INJURY-NECROSIS updated answers.

QUESTION:

Which of the following statements is false regarding necrosis?

A) Necrosis is always pathological

B) Caseous necrosis is most common in the brain

C) Caseous necrosis is characteristic of a tubercular granuloma

D) Morphologically, necrotic cells show increased eosinophilia in a hematoxylin and eosin staining

Answer: B- Liquefactive necrosis occurs in the brain. Caseous necrosis occurs in all organs except the brain

Check this video out for detailed explanation:

Check out this awesome blog for clearing concepts:  https://theartofmed.wordpress.com/2015/05/29/pathologic-cell-injury-and-cell-death-ii-necrosis/amp/

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