MCQ’S GENERAL PATHOLOGY- REVERSIBLE CELL INJURY with answers and explanations

1. A 50 year old man presented with mild abdominal pain with mildly raised ALT and AST.  Fatty liver was suspected,  which of the following changes is not seen ultrastructurally in this condition?

A)  Generalized swelling of cell and plasma membrane.

B)  Nuclear changes such as pyknosis,  karyorrhexis and karyolysis are seen.

C) Accumulation of “myelin figures” in the cytosol composed of phospholipids derived from damaged cellular membranes.

D) Dilation of the ER, with detachment of polysomes.

Answer: B.  Pyknosis,  karyorrhexis and karyolysis are classic features of apoptosis

2. What is the mechanism behind plasma membrane swelling in reversible cell injury?

A)  Influx of water due to direct damage to Na-K-ATPase pump

B)  Plasma menrane damage leading to increased leakiness to sodium ion.

C)  Depletion of ATP resulting in oxygen deficiency interfering in Na-K-ATPase pump activity.

D)  All of the above

Answer:  D

FOR DETAILED EXPLANATION CLICK HERE:

Check out this excellent blog  on more knowledge and details on this topic:  https://theartofmed.wordpress.com/2015/05/29/pathologic-cell-injury-and-cell-death-i-mechanism-of-reversible-cell-injuries/amp/

MCQ’s GENERAL PATHOLOGY- CELL CYCLE (29/03/21)

1.Correctly matched with organ and stem cell niche are all except?

A)  Intestine- crypts

B)  Eyes- limbus of cornea

C)  Brain- periventricular zones

D)  Bone marrow- Paratrabecular area

Answer: D- Bone marrow stem cell niche is – peri-sinisoidal region.

2. Which is the true statement

A)  Rb gene is the key regulator of G2M cell cycle transition.

B) Rb is active in hypophospholylated state

C) MDM2 protein activates p53

D)  p53 activation leads to cell cycle progression

Answer: B – is true, Rb is the regulator of G1/S phase, MDM2 protein inhibits p53 and p53 active leads to transient cell cycle arrest.

Yeaterdays questions with updated answers https://pathologymcqforall.wordpress.com/2021/03/28/mcqs-general-pathology-growth-factors-and-receptors-28-3-20/

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