Posted in pathology, Soft tissue pathology, WEEKLY QUIZZES

SOFT TISSUE AND BONE TUMOR PATHOLOGY QUIZ

SOFT TISSUE AND BONE TUMORS PATHOLOGY QUIZ.

USEFUL FOR

  1. NEET-SS/ DM- Oncopathology/ DM Histopathology
  2. Oncopathology Fellowships
  3. FRCPath- Histopathology and
  4. American Board of anatomic and clinical pathology
  5. Various other boards.

RECENT UPDATES FROM WHO 2020 SOFT TISSUE AND BONE TUMORS

OTHER SBT BLOGS

ILLUSTRATIONS ON THE TOPIC

Posted in Histopathology, Molecular pathology

Molecular pathology of ADIPOCYTIC TUMORS

Molecular pathology of ADIPOCYTIC TUMORS – based on WHO 2020 Soft tissue and bone tumors.

LIPOMAS

The pathogenesis of lipomas is related to reactivated expression of the HMGA2 protein, which plays a role in the development of the mesodermal lineage during embryogenesis

  1. ANGIOLIPOMA– The majority (80%) have been reported to have low-frequency PRKD2 mutations.
  2. CHONDROID LIPOMA– is characterized by a recurrent t(11;16) (q13;p13) chromosomal translocation.
  3. SPINDLE CELL/PLEOMORPHIC LIPOMA: is characterized 13q deletions /RB GENE.
  4. MYOLIPOMA: Cytogenetic alterations of the HMGA2 gene have been reported in a few cases

LIPOSARCOMA

  1. Atypical lipomatous tumour/well differentiated liposarcoma: characterized by supernumerary ring and giant marker chromosomes,containing amplified sequence of MDM2
  2. DEDIFFERENTIATED liposarcomaAmplified MDM2
  3. MYXOID LIPOSARCOMA– Translocations producing FUS-DDIT3 or rarely EWSR1-DDIT3 fusion transcripts are pathognomonic
  4. PLEOMORPHIC LIPOSARCOMA: Complex karyotypes. . The most frequent mutations involve TP53 and NF1.

OTHER ADIPOCYTIC TUMORS

  1. HIBERNOMA: Cytogenetically, almost all hibernomas have breakpoints in chromosome arm 11q, with a distinctive clustering to 11q13.
  2. LIPOBLASTOMA: The most common numerical change is one or more extra copies of chromosome 8, with or without concurrent rearrangement of 8q11-q13

VIEW THE SHORT VIDEO FOR A QUICK SUMMARY