7 Key points- Must know for boards about Secretory carcinoma breast CLICK HERE FOR REVIEW QUESTION Here are 7 key points – Must know for pathology boards about secretory carcinoma of breast Secretory carcinoma of breast in very rare. It harbours unique characteristics which aid in the diagnosis. 1. Secretory carcinoma was earlier known as juvenile breast cancer, but later renamed as secretory carcinoma of breast. This is the most common breast cancer occuring in children. However, it is reported in all age groups. 2. Microscopically, microcystic, tubular or solid pattern may be observed. A combination of the three is also frequent. 3. Intra and extra luminal secretions are present which are PAS- positive and diastase resistant. ETV6- NTRK3 fusion in secretory carcinoma of breast 4. Most tumors have translocation yielding ETV6-NTRK3 fusion gene ( t(12;15). 5. Secretory carcinoma of breast express triple negative molecular phenotype 6. Unlike most triple negative tumors which are TP53 mutant, srcretory carcinomas do not show TP53 mutation. 7. Secretory carcinomas also lack gain of 1q and 16 q loss, characteristic of the low grade tumorigenesis pathway. CLICK HERE FOR REVIEW QUESTION Click below for a quick summary PARIS SYSTEM FOR REPORTING URINARY CYTOLOGY MCQs by Pathology MCQs 22 Mar 2022 Breast Pathology MCQ 1 by Pathology MCQs 12 Mar 2022 CNS Pathology case based MCQs-2 by Pathology MCQs 23 Feb 2022 Liked the page? Why not leave a tip for it’s creators Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...