Free · Gastrointestinal pathology · updated to WHO 6th edition (2026)
GI pathology MCQs, the WHO 6th edition way.
15 board-style questions on the 6th edition Digestive System Tumours: new entities, two-tier grading, amphicrine-like carcinoma, small-duct cholangiocarcinoma and the latest gastric and colorectal biomarkers. Every answer explains why the other options are wrong.
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WHO Digestive 6th ed (2026) · what you will practise
What this GI pathology quiz covers
The questions follow the 6th edition WHO Classification of Digestive System Tumours (2026), which reorganises epithelial tumours by site, gives neuroendocrine, mesenchymal and haematolymphoid tumours their own chapters, simplifies precursor grading to two tiers and adds new entities, plus current biomarker practice.
What is new in the 6th edition
Colorectal intramucosal adenocarcinoma, oesophageal epidermoid metaplasia, sonic hedgehog hepatocellular adenoma, new bile duct intraductal neoplasms, and two-tier grading of precursor lesions.
Neuroendocrine neoplasms
Amphicrine-like carcinoma versus MiNEN, NET G3 versus NEC with p53, Rb, DAXX/ATRX and MEN1, and the enhanced 6th edition grading criteria.
Liver and biliary tract
Small-duct versus large-duct intrahepatic cholangiocarcinoma, FGFR2 fusions and IDH mutations, and the hepatocellular adenoma subtypes.
Colorectum and appendix
Serrated lesion criteria, TSA with conventional dysplasia, MMR testing and Lynch triage, LAMN versus mucinous adenocarcinoma.
Stomach and oesophagus
Claudin 18.2, HER2, PD-L1 and MMR biomarkers in gastric cancer, and anal and oesophageal squamous precursors.
Mesenchymal and treatment-related
SDH-deficient GIST, immune checkpoint inhibitor colitis and the new treatment-associated pathology section.
Frequently asked questions
Is this quiz updated to the WHO 6th edition?
Yes. The questions use the WHO Classification of Digestive System Tumours, 6th edition (2026), including its new entities and two-tier grading, and each explanation cites its source.
Who is it for?
Candidates preparing for INI-SS, NEET-SS and DM Oncopathology, FRCPath Part 1 and Part 2, and MD/DNB pathology, as well as practising pathologists keeping up to date.
Can I see the answer after each question?
Yes. Choose Learn mode to see the answer and explanation after each question, or Test mode to answer all 15 first and review the explanations with your score at the end.
Is the quiz free?
Yes. Enter your name and email once to start; if you are logged in to Pathology MCQ you go straight in.
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