Free · updated to WHO 6th edition

Practise questions, free.

Fourteen open question banks across organ systems and subspecialties, written by practising pathologists and updated to WHO 6th edition. Five of them are whole slide images you can pan and zoom at full resolution. Work through as many as you like, then see where your gaps are.

14Free question banks
5Virtual slide cases
9Organ systems
4Subspecialties


Start with a virtual slide

Five cases · full resolution

The zoomable slide viewer needs JavaScript. All five cases are written out below with their answers.



Scroll to zoom · drag to pan

Dermatopathology

A 34-year-old man has a dark red, slightly verrucous papule on the scrotum. Sections show markedly dilated, thin-walled vascular channels packed with red cells in the papillary dermis. The overlying epidermis is acanthotic and hyperkeratotic, and elongated rete ridges encircle the ectatic vessels. Deeper dermis and subcutis are uninvolved.

Which is the correct diagnosis?

Show answer and teaching point
Teaching pointAnswer: A — AngiokeratomaEctatic papillary dermal vessels with an acanthotic, hyperkeratotic epidermis whose rete ridges collarette the vessels is angiokeratoma. The critical discriminator is depth: angiokeratoma stops at the papillary dermis, whereas verrucous haemangioma extends into deep dermis and subcutis and recurs if shaved. Multiple lesions in a young patient, particularly in a bathing-trunk distribution, should prompt consideration of Fabry disease.
Cytopathology

Conventional cervicovaginal smear from a 29-year-old woman. Squamous cells are coated by a dense layer of small coccobacilli that obscure the cytoplasmic borders. Background lactobacilli are absent and inflammatory cells are sparse.

Which finding is the diagnostic criterion in this smear?

Show answer and teaching point
Teaching pointAnswer: A — Clue cellsSquamous cells coated by coccobacilli to the point that their borders are obscured are clue cells, the cytological hallmark of a shift in vaginal flora suggestive of bacterial vaginosis. Two negatives matter as much as the positive: lactobacilli disappear, and inflammation is characteristically scant, which is why BV is not a vaginitis. Report it descriptively as a shift in flora rather than as a definitive infection. Perinuclear halos are koilocytic change from HPV; pseudohyphae indicate Candida.
Hematopathology

Excised cervical lymph node from a 26-year-old with a solitary painless mass and no systemic symptoms. Follicles are numerous with small, atrophic, hyalinised germinal centres, each penetrated radially by a sclerotic vessel. Mantle zones are expanded into concentric rings. Interfollicular tissue shows prominent hyalinised vasculature. Plasma cells are not increased.

Which is the most likely diagnosis?

Show answer and teaching point
Teaching pointAnswer: A — Unicentric Castleman disease, hyaline-vascular typeA radially penetrating hyalinised vessel gives the lollipop follicle, and concentric mantle expansion gives the onion-skin appearance — together with interfollicular hypervascularity these define hyaline-vascular Castleman disease, which is usually unicentric and cured by excision. The plasma cell variant instead shows hyperplastic germinal centres with interfollicular sheets of plasma cells, is typically multicentric and IL-6 driven, and requires HHV-8 testing. Progressive transformation of germinal centres produces large mantle-cell-rich nodules without lollipops or vascular hyalinisation.
Gastrointestinal

Antral biopsy from a 45-year-old with dyspepsia. The lamina propria contains a dense lymphoplasmacytic infiltrate with lymphoid aggregates. Neutrophils infiltrate the foveolar epithelium and form occasional pit abscesses. Small curved bacilli are visible in the surface mucus layer at high power.

Which statement about this biopsy is correct?

Show answer and teaching point
Teaching pointAnswer: A — Neutrophils within the epithelium define the active componentChronic refers to the lymphoplasmacytic lamina propria infiltrate; active refers specifically to neutrophils within the epithelium, and that distinction is what the terminology is testing. Helicobacter lives in the surface mucus and foveolar pits, not deep glands, and is characteristically lost in intestinal metaplasia — so sample non-metaplastic antrum when hunting for it. Lymphoid aggregates are a consequence of the infection, not an argument against it. When organisms are sparse on H&E, a Giemsa or immunohistochemical stain confirms.
Breast · IHC

Oestrogen receptor immunohistochemistry performed on a core biopsy showing high-grade ductal carcinoma in situ. Strong nuclear staining is present in approximately 80% of tumour cell nuclei. Adjacent normal ducts also show nuclear positivity.

Which statement about reporting this stain is correct?

Show answer and teaching point
Teaching pointAnswer: A — Report the percentage of tumour nuclei stained with intensity; 1% or above is positiveER scoring counts nuclear staining only, reported as the percentage of tumour nuclei stained together with average intensity. Under ASCO/CAP, 1% or above is positive, and 1–10% is reported separately as ER low positive because its predictive value is less certain. Those adjacent normal ducts are your internal positive control — without them a negative result is uninterpretable and the stain must be repeated. ER is worth doing in DCIS: it guides endocrine risk-reduction therapy after surgery.

That is five slides. There are hundreds more.

Virtual slide questions run through the FRCPath, NEET-SS and hematopathology tracks, alongside 5,000+ image-rich MCQs and full-length mocks.

See the courses


Free question banks

Fourteen banks · filter by area









Neuropathology

CNS Tumours

Gliomas, embryonal tumours and meningiomas under the WHO 2021 CNS classification, with the molecular markers that now define them.
Start this quiz →



Head & neck

Salivary Gland Pathology

Benign and malignant salivary tumours, their fusions and the immunopanels that separate the common mimics.
Start this quiz →



Thoracic

Lung, Heart & Mediastinum

Lung carcinoma subtyping, predictive markers, thymic and mediastinal lesions.
Start this quiz →



Soft tissue & bone

Soft Tissue & Bone Tumours

Fusion-driven sarcomas, their immunoprofiles, and the benign lesions they are most often mistaken for.
Start this quiz →



Gastrointestinal

GI Pathology: Quick Answers

Rapid-fire questions on inflammatory patterns, dysplasia grading and GI mesenchymal lesions.
Start this quiz →



Genitourinary

Renal Pathology

Glomerular disease patterns and renal tumour subtypes, including the molecularly defined entities.
Start this quiz →



Dermatopathology

Skin Pathology

Inflammatory patterns, melanocytic lesions and the adnexal tumours that reliably catch people out.
Start this quiz →



Endocrine

Endocrine Pathology

Thyroid, parathyroid, adrenal and neuroendocrine lesions, with the grading systems examiners expect.
Start this quiz →



Gynaecological

Female Genital Tract: Uterus & Ovary

Endometrial and ovarian tumours, molecular classification and the borderline categories.
Start this quiz →



Cytopathology

Cytopathology MCQs

FNAC and fluid cytology across the reporting categories, with the difficult calls worked through.
Start this quiz →



Hematopathology

Hematopathology Question Bank

Smear and marrow morphology, myeloid and lymphoid neoplasms, flow cytometry and defining genetics.
Start this quiz →



Histotechniques

Histotechnology from Bancroft’s

Fixation, processing, staining and troubleshooting — the section most candidates skip and then lose marks on.
Start this quiz →



Molecular

Molecular Techniques

PCR, FISH, sequencing and IHC surrogates — which assay actually answers the clinical question.
Start this quiz →



General pathology

Robbins 10th Edition, Chapterwise

Mechanisms of disease chapter by chapter — the foundation MD/DNB and board papers build their questions from.
Start this quiz →

When you have found your gaps

These are the free ones. There are 5,000 more.

The full bank runs to 5,000+ image-rich MCQs including virtual slide questions, inside a week-by-week curriculum with full-length mocks that score you system by system.

PHP Code Snippets Powered By : XYZScripts.com

You cannot copy content of this page