Familial biparental complete hydatidiform mole (CHM) Familial biparental complete hydatidiform mole (CHM) – An update 👪 Represents 0.6 to 2.6% of CHM. 👪 Mutations of the NLRP7 on chr 19p and KHDC3L on chr 6p. 👪 Conventional CHM are usually of paternal origin (androgenic diploidy) , in contrast to familial CHM which are biparental . 👪 Autosomal recessive inheritance 👪 Patients present with recurrent complete hydatidiform mole.(CHM) 👪 Testing for p57 is negative similar to sporadic CHM. Update WHO 2020 FGT. Review question Which of the following statements is false regarding Familial biparental complete hydatidiform mole (FBCHM)?A) This condition is inherited in an autosomal recessive manner.B) Germline mutations in NLRP7 are commonC) Patients present with recurrent complete hydatidiform mole (CHM)D) P57 testing by Immunohistochemistry (IHC) is positive in cytotrophoblasts unlike complete mole. CLICK TO REVEAL ANSWER Correct answer is D: P57 testing by Immunohistochemistry (IHC) is negative in cytotrophoblasts complete mole both familial and sporadic CHM. You may join telegram channel for chapterwise daily mcqs – Pathology mcqs For pathology mcqs, weekly quizzes, interesting facts and updates – Visit HOME – Pathology for all Join the Facebook page for daily questions- Pathology mcq Useful for NEET-SS Oncopathology, DM Histopathology, FRCPath, and Hematopathology fellowships. Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion.🎯📟PSTT – invasion is periphery to lumen.🎯📟Choriocarcinoma- lumen to periphery. Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Molecular pathogenesis of ovarian epithelial tumors. Molecular progression of serous ovarian tumor. Borderline low and high grade 1.Molecular progression of low grade ovarian serous tumors. There is data to suggest progression from serous cystadenoma / cystadenofibroma with BRAF / KRAS mutations → SBT (serous borderline tumor) → LGSC (Low grade serous carcinoma) ; however, this is still controversial 2. Molecular progression of high grade serous ovarian tumors. TP53 alterations in nearly all cases of high grade serous carcinoma Germline, somatic or promoter hypermethylation (inactivation) of BRCA1 and BRCA2 in ~50% of cases PARIS SYSTEM FOR REPORTING URINARY CYTOLOGY MCQs by Pathology MCQs 22 Mar 2022 Breast Pathology MCQ 1 by Pathology MCQs 12 Mar 2022 CNS Pathology case based MCQs-2 by Pathology MCQs 23 Feb 2022 Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion. Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion. Difference between PSTT ( Placental site trophoblastic tumor) and Choriocarcinoma- Vascular invasion.🎯📟PSTT – invasion is periphery to lumen.🎯📟Choriocarcinoma- lumen to periphery. For more such articles click here Liked the page? Why not leave a tip for it’s creators CNS Pathology case based MCQs-1 by Pathology MCQs 22 Feb 2022 Central nervous system pathology MCQ 1 by Pathology MCQs 13 Feb 2022 Characteristics of Epithelial-Mesenchymal transition by Pathology MCQs 7 Dec 2021 Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...
Pathogenesis of type I and type II Serous Ovarian Carcinomas Pathogenesis of Type I and Type II serous ovarian cancers are entirely different. We will discuss the differences. Most of the human cancers have a steady and known progression curve. Low grade cancers usually progress to high grade. This is not the case in ovarian cancers, high grade and low grade serous carcinoma have different pathogenesis. Unlike most human cancers serous ovarian cancers rarely progress from low grade to high grade PATHOGENESIS OF TYPE I SEROUS OVARIAN CANCERS – Progression Type I ovarian carcinoma is associated with endometriosis, it progresses to serous borderline tumor which may transform to micropapillary serous carcinoma and then into low grade serous carcinoma. Molecular progression of ovarian cancers are shown below. 1.Endometriosis ⬇ 2.Serous borderline tumor ⬇ 3. Micropapillary serous carcinoma ⬇ 4. Low grade serous ovarian carcinoma PATHOGENESIS OF TYPE II SEROUS OVARIAN CANCERS – Progression Type II ovarian carcinoma is associated with simple inclusion cysts, it progresses to serous tubular intraepithelial carcinoma which may transform to high grade serous carcinoma. Simple inclusion cysts 2. STIC Lesions (Serous tubular intraepithelial lesions) 3. High grade serous ovarian carcinoma [table id=1 /] For summary check the post below For similar posts click here. Liked the page? Why not leave a tip for it’s creators Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...