Free · Soft tissue and bone · updated to WHO 6th edition (2026)
Soft tissue and bone MCQs, the WHO 6th edition way.
15 board-style questions on the 6th edition Soft Tissue and Bone Tumours: new entities such as keratin-positive giant cell–rich tumour, YAP1::TFE3 haemangioendothelioma and PATZ1-rearranged sarcoma, plus fusion-defined and round cell sarcomas. Every answer explains why the other options are wrong.
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WHO Soft Tissue & Bone 6th ed (2026) · what you will practise
What this soft tissue and bone quiz covers
The questions follow the 6th edition WHO Classification of Soft Tissue and Bone Tumours (2026, beta), with its new and renamed entities, the molecular alterations that define them and the targeted therapies used in practice.
What is new in the 6th edition
Keratin-positive giant cell–rich tumour, YAP1::TFE3 haemangioendothelioma, TFCP2-rearranged rhabdomyosarcoma, PATZ1-rearranged sarcoma and inflammatory rhabdomyoblastic tumour.
Adipocytic tumours
MDM2 amplification in ALT/WDLPS and atypical spindle cell / pleomorphic lipomatous tumour with Rb loss.
Undifferentiated round cell sarcomas
CIC-rearranged sarcoma and sarcomas with BCOR genetic alterations.
Fusion-defined and targetable sarcomas
SS18::SSX synovial sarcoma, kinase-altered spindle cell neoplasms and NTRK, low-grade fibromyxoid sarcoma.
Vascular tumours
Epithelioid haemangioendothelioma (WWTR1::CAMTA1) versus YAP1::TFE3 haemangioendothelioma.
Bone tumours
H3-3A G34W giant cell tumour and central atypical cartilaginous tumour / chondrosarcoma, grade 1.
Frequently asked questions
Is this quiz updated to the WHO 6th edition?
Yes. Five questions cover new entities in the WHO Classification of Soft Tissue and Bone Tumours, 6th edition (2026), and the rest cover fusion-defined sarcomas and molecular testing with 6th edition terminology. Each explanation cites its source.
Who is it for?
Candidates preparing for INI-SS, NEET-SS and DM Oncopathology, FRCPath Part 1 and Part 2, and MD/DNB pathology, as well as practising pathologists keeping up to date.
Can I see the answer after each question?
Yes. Choose Learn mode to see the answer and explanation after each question, or Test mode to answer all 15 first and review the explanations with your score at the end.
Is the quiz free?
Yes. Enter your name and email once to start; if you are logged in to Pathology MCQ you go straight in.
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