Based on WHO 2022 Tumors of the Female Genital Tract.

1. CONVENTIONAL- SPINDLE CELL LEIOMYOSARCOMA

2 or more of the following

• Marked cytologic atypia
• Tumor cell necrosis
• >= 10 mitosis / 10 HPF (High power field) OR >= 4 mitosis/mm2

2. EPITHELIOID LEIOMYOSARCOMA

1 or more of the following

• Moderate to severe cytologic atypia
• Tumor cell necrosis
• >= 4 mitosis / 10 HPF (High powers field) OR >=1.6 mitosis/mm2

3. MYXOID LEIOMYOSARCOMA

1 or more of the following

• Moderate to severe cytologic atypia
• Tumor cell necrosis
• >= 1 mitosis / 10 HPF (High power field) OR > 1 mitosis/mm2
• Infiltrative borders/ irregular margins.

Try to answer the MCQ below

Which of the following is true regarding leiomyosarcomas?

Correct answer is Mitotic count essential for the diagnosis of Myxoid Leiomyoma is >1/10 HPF

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