Melanoma- Genetic mutations

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1.

A 45-year-old woman presents with a pigmented lesion on the sole of her foot that has increased in size over six months. Biopsy shows atypical melanocytes extending into the dermis with spindle cell features. Which genetic mutation is most likely responsible for this lesion?

A. BRAF

B. NRAS

C. KIT

D. GNA11

2.

A 50-year-old woman with a history of multiple congenital nevi presents with a pigmented lesion arising from one of these nevi. Histology reveals atypical melanocytes and molecular testing identifies an NRAS mutation. What is the most likely diagnosis?

A. Nodular Melanoma

B. Superficial Spreading Melanoma

C. Melanoma arising in Congenital Nevus

D. Desmoplastic Melanoma

3.

A 55-year-old man presents with a mass in the orbit causing visual disturbances. Imaging reveals a pigmented intraocular tumor. Biopsy shows spindle-shaped melanocytes with minimal pleomorphism. Which genetic mutation is most likely involved?

A. NRAS

B. BRAF

C. GNAQ

D. KIT

Melanoma- Genetic mutations

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