Types of Ameloblastoma
One tumor. Distinct histologic patterns. Recognize the microscopic clues.
NEET-SS Oncopathology Online Course 3.0V
Recognize the architecture first, then identify the defining cellular features.
This illustrated guide walks through the six recognized histologic patterns of ameloblastoma — each with an annotated H&E image, key microscopic features and a one-line recognition clue.
It closes with a concise reference to the positive immunostains and the molecular genetics of ameloblastoma.
of ameloblastomas harbor mutations in genes belonging to the MAPK pathway. BRAF V600E is the most common mutation; KRAS, NRAS, HRAS and FGFR2 alterations also occur.
The microscopic architecture tells them apart
Follicular
Epithelial islands with peripheral palisading around stellate-reticulum-like central cells.
Plexiform
Interconnected cords and strands forming an anastomosing network.
Acanthomatous
Squamous metaplasia and variable keratinization within tumor islands.
Granular cell
Stellate-reticulum-like cells with abundant, coarse granular eosinophilic cytoplasm.
Basaloid
Hyperchromatic basal-like cells with inconspicuous stellate-reticulum-like areas.
Desmoplastic
Compressed, angular epithelial islands within dense collagenous stroma.
Learning benefits
Built for NEET-SS Oncopathology preparation and routine sign-out.
Pattern recognition
Distinguish all six histologic patterns from annotated H&E images.
Recognition clues
One-line diagnostic clues and key microscopic features for every pattern.
IHC at a glance
Positive immunostains — CK19, CK14, CK5, CD56, Calretinin, BRAF V600E.
Molecular genetics
The MAPK pathway, BRAF V600E and related KRAS, NRAS, HRAS and FGFR2 mutations.
Preview the guide
Swipe through the pages, then view or download the full guide.
NEET-SS Oncopathology Online Course 3.0V
Concepts & principles, high yield notes, 8 grand mock tests and MCQs per topic.
