Clinical Hematology MCQs- 3

Posted on 23 Jul 202123 Jul 2021 by pathologymcqs

Welcome to your Clinical Hematology MCQs- 3

1. You are asked to review a peripheral blood smear from a 19-year-old woman with sickle cell disease (homozygous hemoglobin S). An RBC inclusion is identified and is shown in the picture. The inclusion is composed of which one of the following constituents?

A. Denatured hemoglobin.

B. Denatured hemoglobin H.

C. DNA.

D. Iron.

E. RNA.

2. Which one of the following disorders is associated with the cell indicated by the arrow in the picture?

A. Hemoglobin C disease (homozygous hemoglobin C).

B. Hemoglobin SD disease (double heterozygous hemoglobin S and hemoglobin D).

C. Hereditary elliptocytosis.

D. Plasmodium falciparum.

E. Microangiopathic hemolytic anemia.

3. A sickle solubility test is performed by adding sodium hydrosulfite in a phosphate buffer to a hemolysate. If hemoglobin S is present, it will be reduced and form liquid crystals, which turn the solution cloudy. Which one of the following disorders can cause a false-positive sickle solubility test result?

A. Severe anemia.

B. Deglycerolized red cells.

C. Elevated hemoglobin F.

D. Hypergammaglobulinemia.

E. Newborn.