CNS Pathology MCQ + DISCUSSION

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1.

Most IDH- mutant diffuse astrocytomas have which of the following mutations?

A. R132G

B. R132L

C. R132H

D. R132S

2.

LRRK2 mutation is associated with which of the following conditions?

A) Alzheimer disease

B) Parkinson’s disease

C) Frontotemporal dementia

D) Multiple system atrophy

3.

Identify the condition from squash cytology image?

A. Ependymoma

B. Oligiodendroglioma

C. Glioblastoma

D. Medulloblastoma

4.

After a bat bite, a rural farmer suffers from flu-like symptoms. Over the following days he develops diffuse weakness and confusion and is dead within 1 month. The following image was taken from autopsy. What is the name of the pathognomonic findings indicated by the arrows?

A. Negri bodies

B. Cowdry type A

C. Cowdry type B

D. Howell-Jolly bodies

5.

A 40-year-old woman underwent muscle biopsy for progressive weakness, among other symptoms. Which of the following is her most likely diagnosis based on the image shown?

A. Emery-Dreifuss muscular dystrophy

B. Dermatomyositis

C. Polymyositis

D. Conversion disorder

CNS Pathology MCQ + DISCUSSION

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