Review question 1- APML

Welcome to your Review question 1- APML

A 40- year old female presented to the emergency with fatigue for 1 week and heavy nosebleed for the past few hours. CBC – Hb- 7.5g/dl WBC- 50 x 109 per liter Platelet count – 10,000 per microliter Peripheral smear shows the finding in the image. Which of the following is false regarding this condition?

False about this condition?

A. Most commonly associated with PML-RARA fusion detectable by in- situ hybridization.

B. FLT3-ITD mutations are also common with this morphology.

C. ZBTB16-RARA fusion carries a worse prognosis due to treatment resistance

D. STAT5B-RARA fusion also carries a worse prognosis due to treatment resistance.

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