Pathology MCQs for various entrance exams

Welcome to your Breast pathology – IHC MCQs

1. All of the following are true regarding classical lobular carcinoma in situ (LCIS)except?

A. Loss of membranous expression of E-cadherin is the defining immunohistochemical feature of classic LCIS

B. Strong and diffuse ER and PR nuclear positivity

C. Presence of mucin vacuoles

D. Strong membranous positivity for Her-2 new in most of the cases.

2. Which of the following immunohistochemistry profiles favour paget's disease over squamous cell carcinoma in situ( bowens disease)?

A. Her2 /Cam 5.2/GCDFP-15 -Positive

B. HMWK positive and GCDFP-15 negative

C. PAS and mucicarmine negative

D. Melan A positive and HMWK positive

3. All are true regarding immunohistochemistry of breast carcinoma except?

A. 10-30% of ductal breast carcinoma are positive for Her-2

B. GATA 3 is a nuclear marker seen on >90% of breast carcinoma

C. SOX 10 expression is enriched in triple negative breast cancers

D. HMWK (P63 and p40) are positive in microglandular adenosis

Breast pathology – IHC MCQs