1. Which of the following is found in platelet α-granules?
2. A 4-year-old boy is brought to the pediatrician for frequent nosebleeds and gingival bleeding, which are occasionally severe. There is no history of bleeding disorders in the mother, father, or two older brothers. The CBC shows hemoglobin 11.8 g/dL and platelets 160 × 109/L. Light transmission aggregometry on platelet-rich plasma is shown in picture below. Which antibody is most likely present in the boy?Aggregometry
3. Which disorder most likely explains the findings on the platelet aggregation studies shown in picture?Light aggregometry
4. Which inherited platelet disorder is associated with a mutation in the gene for the thrombopoietin (TPO) receptor (MPL)?
5. A 15-year-old woman with a history of bruising and thrombocytopenia her entire life presents to a hematologist. Her review of systems is otherwise negative. Results of her CBC are normal except for a platelet count of 20,000/ microliter and examination of the peripheral smear demonstrates platelets the size of the surrounding red blood cells (RBCs) and Döhle-like bodies in neutrophils. This presentation is most consistent with which platelet disorder?
6. Which of the following could best explain a falsely elevated platelet count enumerated on an impedance-based automated hematology analyzer?
7. Which of the following coagulation factor deficiencies is not associated with beeding?
8.An 18-year-old man with a history of von Willebrand disease (vWD) is scheduled to undergo wisdom-tooth extraction. In preparation for his procedure, his hematologist is planning to perform a trial of desmopressin (DDAVP) to see whether he responds. In which one of the following types of von Willebrand disease has DDAVP been known to cause thrombocytopenia?
9. Which of the following coagulation factor deficiencies is associated with amyloidosis
10. Which one of the following clotting factors has the longest plasma half-life?
11.Which one of the following reasons makes it difficult to treat actively bleeding patients with congenital factor VII deficiency using recombinant factor VIIa?
12. Which immunoassay is the most reliable in supporting the diagnosis of antiphospholipid antibody syndrome?
13. The parents of a 1-year-old boy report that he has begun to experience episodes of severe pain in his ankles and knees since beginning to walk. His laboratory results are all normal except for a prolondef APTT.His APTT mixing studies revealed immediate and 2-h incubated mix correction. What is the logical next step?
14. A patient presents for follow-up and warfarin monitoring by INR 2 months after an episode of venous thrombosis. At this visit, his physician decides to also run a thrombophilia profile to determine the etiology of the thrombosis. He receives laboratory results that report concurrent protein C and protein S activity deficiencies, but no other inherited thrombophilia indications. What is the best explanation for these results?
15. Which assay is typically used to confirm HIT?
16. When HIT is suspected, which of the following anticoagulant therapies may be substituted for UFH?
17.A 40- year- old woman with fever and epigastric pain of four days’ duration presents to the emergency room. Her hematocrit is 24%, platelet count is 15 × 10 3 / L, LDH is 899 U/ L and peripheral smear shows schistocytes. What is the cause of this disorder?
18. Activated protein C resistance due to Factor V Leiden is caused by which of the following?
19. Antiphospholipid syndrome (APS) has which of the following characteristics?
20.Which of the following disorders is inherited in an autosomal recessive fashion?
Pathology Mcqs


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