LIVER, GALL BLADDER AND PANCREAS PATHOLOGY- QUIZ ANSWERS LIVER, GALL BLADDER AND PANCREAS PATHOLOGY- QUIZ ANSWERS PLEASE WAIT FOR A WHILE FOR ANSWERS TO APPEAR AFTER SELECTING THE ANSWER Which is true regarding normal histology of the liver? Zone 3 is the area around the portal tracr Zone 1 is the area around the central venule Hepatocytes stain for keratins CK8 and CK 18 CK 7 is never expressed in hepatocytes and has no significance Identify the stage of fibrosis based on Scheuer staging from the picture Stage 2 Stage 3 Stage 1 Stage 4 A 40-year old female presents with yellowish discoloration of skin and sclera. Total bilirubin, AST and ALT are elevated. Serologic study revealed presence of ANA antibodies which of the following histological features are seen in this condition? The predominant histologic finding is interface and lobular hepatitis, often with prominent plasma cells. Balooning degeneration of hepatocytes Presence of ground glass hepatocytes Presence of mallory hyaline bodies Which of the following HCV genotypes is associated with severe steatosis? HCV genotype 3c HCV genotype 3a HCV genotype 3d HCV genotype 3e Which findings favour Alcoholic liver disease over NASH? Mallory hyaline bodies Neutrophil satellitosis Severe hepatocyte balooning All of the above The pictures show staining pattern of hepatocytes in chronic cholestatic hepatitis compared to normal hepatocytes. Identify stain 1 and Stain 2 from the picture. CD34 and HEP-Par 1 CK 8 and CK 18 CK 7 and CK 19 CK 7 and Orcein Which of the following is true regarding types of progressive familial intrahepatic cholestasis (PFIC)? All three types have the same genetics PFIC - 3 is associated with MDR- deficiency All three types have elevated GGT ( gamma glutamyl transferase) All of the above A liver biopsy from a patient with a cirrhotic liver shows the following findings (in the picture prussian blue). All of the following gene mutations can cause this condition except? HFE Hemojuvelin Transferrin receptor type 2 TMPRSS2 Characteristic map like staining pattern of glutamine synthase is seen in? Focal nodular hyperplasia Hepatocellular adenoma Primary biliary cirrhosis Hepatocellular carcinoma Which of the following viral protein is responsible for the liver biopsy finding in a patient with Hepatitis-B? HbSAg HbcAg HbeAg anti-Hbc Which of the following findings favour the diagnosis of FNH over hepatic adenoma? Homogenous cell population Perivascular patchy positivity for glutamine synthase Chronic inflammatory infiltrates in the parenchyma Presence of ductular reaction and fibrous bands A middle aged woman presents with pruritis. Lab testing reveals elevated liver enzymes and alkaline phosphatase. A liver biopsy shows the finding in picture? Which of the following is most likely to be elevated in her serum? Anti mitochondrial antibodies Anti nuclear antibody Anti liver kidney microsomal antibody Anti smooth muscle anti body True regarding dysplastic nodules in liver High grade dysplastic nodules are large and often visible grossly High grade dysplastic nodules harbour large cell dysplasia change microscopically Dysplastic nodules always aise from non cirrhotic liver Low grade dysplastic nodules can be distinguished grossly from background cirrhotic liver Which of the following has high diagnostic value in distinguishing dysplastic nodule and hepatocellular carcinoma? Unpaired arteries Nodule in nodule appearance Reticulin formation Presence of pseudoglands and acini According to the molecular subtyping of hepatocellular carcinoma, which of the following subtypes are associated with TSC1/TSC2 mutation Schirrous Steatohepatitis subtupe Fibrolamellar Macrotubular massive subtype A 25-year old male presented with mild epigastic pain for three weeks. A CT scan of abdomen performed shows, single large tumor in the liver with dense fibrotic bands forming a central scar. Surgical excision was performed, H&E image is shown below. All of the following statements are true about this tumor except? . > 95% are positive for DNAJB1-PRAKA fusion gene Alfa fetoprotein is not elevated This tumor develops in the background of chronic liver disease. Common in individuals <40 years A 32-year female presented with dull epigastric pain for 6-7 months not releived by medications. In USG and CT a cystic lesion with internal septae and calcification was noted in the tail of pancreas. Gross examination and microscopy showed the image given below. Which of the following immunohistochemical markers will most likely be positive in this lesion? BRAF Progesterone N-RAS Beta-catenin Which of the following pancreatic neoplasms is associated with Beta-catenin mutations in more than 90% cases Mucinous cystadenoma Intraductal papillary mucinous neoplasms Solid pseudopapillary neoplasms of pancreas Serous cystadenoma All of the following are driver mutations associated with the carcinogenesis of pancreatic carcinoma except? APC KRAS SMAD TP53 Which of the following subtypes of hepatocellular adenoma is associated with severe steatosis? SHH mutated subtype HIF-1a mutated subtype Beta catenin mutated subtype Activation of IL-6/JAK-STAT Time is Up! Time's up Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...