LIVER, GALL BLADDER AND PANCREAS PATHOLOGY- QUIZ ANSWERS Posted on 1 Jun 2021 by pathologymcqs LIVER, GALL BLADDER AND PANCREAS PATHOLOGY- QUIZ ANSWERS PLEASE WAIT FOR A WHILE FOR ANSWERS TO APPEAR AFTER SELECTING THE ANSWER Which is true regarding normal histology of the liver?Zone 3 is the area around the portal tracrZone 1 is the area around the central venuleHepatocytes stain for keratins CK8 and CK 18CK 7 is never expressed in hepatocytes and has no significance Identify the stage of fibrosis based on Scheuer staging from the pictureStage 2Stage 3Stage 1Stage 4 A 40-year old female presents with yellowish discoloration of skin and sclera. Total bilirubin, AST and ALT are elevated. Serologic study revealed presence of ANA antibodies which of the following histological features are seen in this condition?The predominant histologic finding is interface and lobular hepatitis, often with prominent plasma cells.Balooning degeneration of hepatocytesPresence of ground glass hepatocytesPresence of mallory hyaline bodies Which of the following HCV genotypes is associated with severe steatosis?HCV genotype 3cHCV genotype 3aHCV genotype 3dHCV genotype 3e Which findings favour Alcoholic liver disease over NASH?Mallory hyaline bodiesNeutrophil satellitosisSevere hepatocyte balooningAll of the above The pictures show staining pattern of hepatocytes in chronic cholestatic hepatitis compared to normal hepatocytes. Identify stain 1 and Stain 2 from the picture.CD34 and HEP-Par 1CK 8 and CK 18CK 7 and CK 19CK 7 and Orcein Which of the following is true regarding types of progressive familial intrahepatic cholestasis (PFIC)?All three types have the same geneticsPFIC - 3 is associated with MDR- deficiencyAll three types have elevated GGT ( gamma glutamyl transferase)All of the above A liver biopsy from a patient with a cirrhotic liver shows the following findings (in the picture prussian blue). All of the following gene mutations can cause this condition except?HFEHemojuvelinTransferrin receptor type 2TMPRSS2 Characteristic map like staining pattern of glutamine synthase is seen in?Focal nodular hyperplasiaHepatocellular adenomaPrimary biliary cirrhosisHepatocellular carcinoma Which of the following viral protein is responsible for the liver biopsy finding in a patient with Hepatitis-B?HbSAgHbcAgHbeAganti-Hbc Which of the following findings favour the diagnosis of FNH over hepatic adenoma?Homogenous cell populationPerivascular patchy positivity for glutamine synthaseChronic inflammatory infiltrates in the parenchymaPresence of ductular reaction and fibrous bands A middle aged woman presents with pruritis. Lab testing reveals elevated liver enzymes and alkaline phosphatase. A liver biopsy shows the finding in picture? Which of the following is most likely to be elevated in her serum?Anti mitochondrial antibodiesAnti nuclear antibodyAnti liver kidney microsomal antibodyAnti smooth muscle anti body True regarding dysplastic nodules in liverHigh grade dysplastic nodules are large and often visible grosslyHigh grade dysplastic nodules harbour large cell dysplasia change microscopicallyDysplastic nodules always aise from non cirrhotic liverLow grade dysplastic nodules can be distinguished grossly from background cirrhotic liver Which of the following has high diagnostic value in distinguishing dysplastic nodule and hepatocellular carcinoma?Unpaired arteriesNodule in nodule appearanceReticulin formationPresence of pseudoglands and acini According to the molecular subtyping of hepatocellular carcinoma, which of the following subtypes are associated with TSC1/TSC2 mutationSchirrousSteatohepatitis subtupeFibrolamellarMacrotubular massive subtype A 25-year old male presented with mild epigastic pain for three weeks. A CT scan of abdomen performed shows, single large tumor in the liver with dense fibrotic bands forming a central scar. Surgical excision was performed, H&E image is shown below. All of the following statements are true about this tumor except? .> 95% are positive for DNAJB1-PRAKA fusion geneAlfa fetoprotein is not elevatedThis tumor develops in the background of chronic liver disease.Common in individuals <40 years A 32-year female presented with dull epigastric pain for 6-7 months not releived by medications. In USG and CT a cystic lesion with internal septae and calcification was noted in the tail of pancreas. Gross examination and microscopy showed the image given below. Which of the following immunohistochemical markers will most likely be positive in this lesion?BRAFProgesteroneN-RASBeta-catenin Which of the following pancreatic neoplasms is associated with Beta-catenin mutations in more than 90% casesMucinous cystadenomaIntraductal papillary mucinous neoplasmsSolid pseudopapillary neoplasms of pancreasSerous cystadenoma All of the following are driver mutations associated with the carcinogenesis of pancreatic carcinoma except?APCKRASSMADTP53 Which of the following subtypes of hepatocellular adenoma is associated with severe steatosis?SHH mutated subtypeHIF-1a mutated subtypeBeta catenin mutated subtypeActivation of IL-6/JAK-STAT Time is Up! Related Author: pathologymcqs Daily MCQ's and updates will be posted for various entrance exams View All Posts
Very nice questions. Thanks for giving us this opportunity to solve them. Keep up this good work 🙏🏼🙏🏼🙏🏼 Reply
Nice questions
Very nice questions. Thanks for giving us this opportunity to solve them.
Keep up this good work 🙏🏼🙏🏼🙏🏼